Tetracyclic derivatives; process of preparation and use

  • US 5,859,006 A
  • Filed: 07/16/1996
  • Issued: 01/12/1999
  • Est. Priority Date: 01/21/1994
  • Status: Expired due to Term
First Claim
Patent Images

1. A compound of formula (I) ##STR20## or salts or solvates thereof, in which:

  • R0 represents hydrogen, halogen or C1-6 alkyl;

    R1 represents hydrogen, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, haloC1-6 alkyl, C3-8 cycloalkyl, C3-8 cycloalkylC1-3 alkyl, arylC1-3 alkyl, wherein aryl is phenyl or phenyl substituted with one to three substituents selected from the Group consisting of halogen, C1-6 alkyl, C1-6 alkoxy, methylenedioxy, and mixtures thereof, or heteroarylC1-3 alkyl, wherein heteroaryl is thienyl, furyl, or pyridyl, each optionally substituted with one to three substituents selected from the group consisting of halogen, C1-6 alkyl, C1-6 alkoxy, and mixtures thereof;

    R2 represents an optionally substituted mono-cyclic aromatic ring selected from benzene, thiophene, furan and pyridine or an optionally substituted bicyclic ring ##STR21## attached to the rest of the molecule via one of the benzene ring carbon atoms and wherein the fused ring A is a 5- or 6-membered ring which may be saturated or partially or fully unsaturated and comprises carbon atoms and optionally one or two heteroatoms selected from oxygen, sulphur and nitrogen; and

    R3 represents hydrogen or C1-3 alkyl, or R1 or R3 together represent a 3- or 4-membered alkyl or alkenyl chain component of a 5- or 6-membered ring.

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