Photonic molecular probe

• US 5,871,442 A
• Filed: 05/19/1997
• Issued: 02/16/1999
• Est. Priority Date: 09/10/1996
• Status: Expired due to Fees

• Current Assignee: Xoetronics LLC
• Original Assignee: International Diagnostic Technologies Incorporated
• Inventors: Wyly, James, Madarasz, Frank, Engelhaupt, Darell, Milelli, Joseph
• Primary Examiner(s): O'Connor, Cary E.
• Assistant Examiner(s): WINAKUR, ERIC FRANK
• Application Number:
  US08/858,260
• Time in Patent Office: 638 Days
• Field of Search: 600/310, 600/316, 600/318, 600/319, 356/364, 356/366, 356/367
• US Class Current: 600/310
• CPC Class Codes: A61B 5/14558 by polarisation
• CPC Class Codes: A61B 5/7203 for noise prevention, reduction or removal
• CPC Class Codes: A61B 5/726 using Wavelet transforms
• CPC Class Codes: G01N 21/21 Polarisation-affecting properties G01N21/19 takes precedence

Abstract

An opto-electronic device utilizes a band of polychromatic light for quantitative analysis of a target molecule within a mixed specimen. A movable polarizer produces a segmented band of partially polarized polychromatic light from the band of partially polarized polychromatic light. A specimen cell adapted for receiving the mixed specimen transports the segmented band of partially polarized polychromatic light to the mixed specimen. A movable polarizing analyzer is optically coupled to the segmented band of partially polarized polychromatic light exiting the mixed specimen. The segmented band of partially polarized polychromatic light before entering the mixed specimen is compared with the segmented band of partially polarized polychromatic light after exiting the mixed specimen. The movable polarizer is synchronized with the movable polarizing analyzer. Additionally a frequency filter can be optically coupled to the movable polarizer, where the frequency filter produces a beam of single frequency ellipitically polarized light from the band of partially polarized polychromatic light such that the segmented band of partially polarized polychromatic light is a segmented band of ellipitically polarized light.

Claims

1. An opto-electronic device utilizing a band of partially polarized polychromatic light for quantitative analysis of a target molecule within a mixed specimen, said device comprising:

a movable polarizer for producing a segmented band of partially polarized polychromatic light from the band of partially polarized polychromatic light;

a specimen cell adapted for receiving the mixed specimen and for transporting said segmented band of partially polarized polychromatic light to the mixed specimen;

a movable polarizing analyzer optically coupled to said segmented band of partially polarized polychromatic light exiting the mixed specimen; and

comparison means for comparing said segmented band of partially polarized polychromatic light before entering the mixed specimen with said segmented band of partially polarized polychromatic light after exiting the mixed specimen,

wherein said movable polarizer is synchronized with said movable polarizing analyzer.

2. The device as recited in claim 1 further comprising a frequency filter optically coupled to said movable polarizer, wherein said frequency filter produces a beam of single frequency ellipitically polarized light from the band of partially polarized polychromatic light such that said segmented band of partially polarized polychromatic light is a segmented band of ellipitically polarized light.

3. The device as recited in claim 1 wherein said band of partially polarized polychromatic light includes frequencies which interact strongly with the target molecule.

4. The device as recited in claim 1 wherein said band of partially polarized polychromatic light comprises infrared light.

5. The device as recited in claim 1 wherein said band of partially polarized polychromatic light comprises ultraviolet light.

6. The device as recited in claim 1 further comprising an RF source coupled to said specimen cell whereby said RF source causes particular changes of selected achiral molecules within the mixed specimen.

7. The device as recited in claim 1 wherein said comparison means further comprises a photo detector.

8. The device as recited in claim 1 wherein said comparison means further comprises a spectrometer.

9. The device as recited in claim 1 further comprising a frequency filter for producing a single frequency elliptically polarized light band from said band of partially polarized polychromatic light.

10. The device as recited in claim 1 wherein said movable polarizer is incrementally rotatable.

11. The device as recited in claim 1 wherein said movable polarizing analyzer is incrementally rotatable.

12. The device as recited in claim 1, wherein said comparison means further comprises a signal processor for determining a quantitative level of the target molecule within the mixed specimen.

13. The device as recited in claim 12, wherein said quantitative level corresponds to a glucose level.

14. The device as recited in claim 12, wherein said quantitative level corresponds to an ethanol level.

15. The device as recited in claim 12, wherein said quantitative level corresponds to a drug serum level.

16. The device as recited in claim 12, wherein said quantitative level corresponds to a hormone serum level.

17. The device as recited in claim 12, wherein said quantitative level corresponds to a triglycerides level.

18. An opto-electronic device utilizing a band of partially polarized polychromatic light for quantitative analysis of a target molecule within a mixed specimen, said device comprising:

a frequency filter for producing a beam of elliptically polarized light from the band of partially polarized polychromatic light;

a polarizer for producing segmented characterized light by rotating said polarizer, said elliptically polarized light optically coupled to said

a specimen cell adapted for receiving the mixed specimen so that said segmented characterized light is brought onto and through the mixed specimen;

a movable polarizing analyzer optically coupled to segmented characterized light exiting the mixed specimen; and

comparison means for comparing said segmented characterized light before entering the mixed specimen with said segmented characterized light after exiting the mixed specimen,

wherein when said polarizer is rotated to a selected position, said movable polarizing analyzer is scanned from a predetermined position through a predetermined range.

19. The device as recited in claim 18 wherein said segmented characterized light includes frequencies which interact strongly with the target molecule.

20. The device as recited in claim 18 wherein said partially polarized polychromatic light comprises infrared light.

21. The device as recited in claim 18 wherein said partially polarized polychromatic light comprises ultraviolet light.

22. The device as recited in claim 18 further comprising an RF source coupled to said specimen cell whereby said RF source causes a state change of selected achiral molecules within the mixed specimen.

23. The device as recited in claim 18 wherein said comparison means further comprises a photo detector.

24. The device as recited in claim 18 wherein said comparison means further comprises a spectrometer.

25. The device as recited in claim 18 wherein said polarizer is incrementally rotatable.

26. The device as recited in claim 18 wherein said movable polarizing analyzer is incrementally rotatable.

27. The device as recited in claim 18, wherein said comparison means further comprises a signal processor for determining a quantitative level of the target molecule within the mixed specimen.

28. The device as recited in claim 27, wherein said quantitative level corresponds to a glucose level.

29. The device as recited in claim 27, wherein said quantitative level corresponds to an ethanol level.

30. The device as recited in claim 27, wherein said quantitative level corresponds to a drug serum level.

31. The device as recited in claim 27, wherein said quantitative level corresponds to a hormone serum level.

32. The device as recited in claim 27, wherein said quantitative level corresponds to a triglycerides level.

33. A method for quantitative analysis of a target molecule within a mixed specimen, said method comprising the steps of:

producing elliptical/partially polarized polychromatic light;

producing segmented characterized light by rotating a polarizer optically coupled to said elliptical/partially polarized polychromatic light;

transporting said segmented characterized light onto and through the mixed specimen;

polarizing said segmented characterized light exiting the mixed specimen; and

comparing said segmented characterized light before entering the mixed specimen with said segmented characterized light after exiting the mixed specimen,

wherein the step of producing segmented characterized light is synchronized with the step of polarizing said segmented characterized light.

34. The method as recited in claim 33 further comprising the step of determining a quantitative level of the target molecule within the mixed specimen.

35. The method as recited in claim 34, wherein said quantitative level corresponds to a glucose level.

36. The method as recited in claim 34, wherein said quantitative level corresponds to an ethanol level.

37. The method as recited in claim 34, wherein said quantitative level corresponds to a drug serum level.

38. The method as recited in claim 34, wherein said quantitative level corresponds to a hormone serum level.

39. The method as recited in claim 34, wherein said quantitative level corresponds to a triglycerides level.

40. The method as recited in claim 33 further comprising the step of coupling an RF source to the mixed specimen whereby said RF source causes particular changes of selected achiral molecules within the mixed specimen.