Implantable drug delivery means

• US 5,871,478 A
• Filed: 01/31/1996
• Issued: 02/16/1999
• Est. Priority Date: 08/11/1993
• Status: Expired due to Fees

• Current Assignee: Thomas John Berrigan
• Original Assignee: Thomas John Berrigan
• Inventors: Berrigan, Thomas John
• Primary Examiner(s): DeMille, Danton D.
• Application Number:
  US08/591,450
• Time in Patent Office: 1,112 Days
• Field of Search: 604/9, 604/10, 604/93, 604/131, 604/132, 604/175, 604/185, 604/891.1, 604/151, 604/153, 128/DIG. 12
• US Class Current: 604/891.1
• CPC Class Codes: A61M 5/1428 with manual pumping action
• CPC Class Codes: Y10S 128/12 Pressure infusion

Abstract

A subcutaneous drug delivery means which comprises a holding reservoir (11), a pumping means (15), a delivery reservoir (18) and an outlet (21). The holding reservoir (11) is connected to the delivery reservoir (18) through the pump (15) which is operable manually to deliver fluid from the holding reservoir (11) to the delivery reservoir (18). The delivery reservoir (18) is resiliently expandable from a minimum volume to a maximum volume and is connected to the outlet (21) through a flow restriction means (23) which controls flow to the outlet.

Claims

1. A drug delivery device comprising a holding reservoir, a pump, a delivery reservoir and an outlet, said holding reservoir being connected to said delivery reservoir through said pump by a connection, said pump being operable manually whereby fluid is transferred from the holding reservoir to the delivery reservoir, said delivery reservoir being connected to the outlet through a flow restriction which controls flow to the outlet, said delivery reservoir being resiliently expandable from a minimum volume to a maximum volume whereby the pressure induced on the fluid within the delivery reservoir between the minimum volume and the maximum volume provides a substantially constant rate of fluid delivery and wherein the connection between the holding reservoir and the delivery reservoir permits flow only from the holding reservoir to the delivery reservoir while the pressure within the delivery reservoir is less than a maximum pressure, said connection having a control means for redirecting flow to the holding reservoir upon the pressure within the delivery reservoir attaining said maximum pressure.

2. An implantable drug delivery device as claimed in claim 1 wherein the control means comprises a first valve between the holding reservoir and the pump and a second valve between the pump and the delivery reservoir, said first and second valve permitting unidirectional flow to the pump and the delivery reservoir respectively, while said delivery reservoir is not filled to its maximum volume and the pressure within the delivery reservoir is below the maximum pressure, the second valve permitting flow to the holding reservoir while the pressure within said delivery reservoir is at least equal to the maximum pressure.

3. A drug delivery device as claimed in claim 1 wherein the control means comprises a relief valve between the delivery reservoir and the holding reservoir which will permit flow from the delivery reservoir to the holding reservoir when the fluid pressure in the delivery reservoir is at least equal to the maximum pressure.

4. A drug delivery device as claimed in claim 1 wherein the flow restriction is provided with a plurality of flow pathways.

5. A drug delivery device as claimed in claim 4 wherein the flow restriction comprises a plurality of capillary passageways.

6. A drug delivery device as claimed in claim 4 wherein the flow restriction comprises a porous element.

7. A drug delivery device as claimed in claim 6 wherein the porous element is formed of glass, ceramic or like inert material.

8. A drug delivery device as claimed in claim 1 wherein the flow restriction comprises a single passageway and a filter located upstream from the passageway.

9. A drug delivery device as claimed in claim 1 wherein the delivery reservoir is enclosed by an enclosure having non-expandable walls to prevent the expansion of the delivery reservoir beyond the maximum volume.

10. A drug delivery device as claimed in claim 9 wherein the walls of the enclosure are rigid.

11. A drug delivery device as claimed in claim 9 wherein the walls of the enclosure are flexible.

12. A drug delivery device as claimed in claim 1 wherein the walls of the delivery reservoir are adapted to be incapable of expansion beyond the maximum volume.

13. A drug delivery device as claimed in claim 1 wherein the minimum volume comprises a volume of the delivery reservoir between the maximum volume and a reservoir minimum volume.

14. A drug delivery device comprising a holding reservoir, a pump, a delivery reservoir and an outlet, said holding reservoir being connected to said delivery reservoir through said pump by a connection, said pump being operable manually whereby fluid is transferred from the holding reservoir to the delivery reservoir, said delivery reservoir being connected to the outlet through a flow restriction which controls flow to the outlet, said delivery reservoir being resiliently expandable from a minimum volume to a maximum volume whereby the pressure induced on the fluid within the delivery reservoir between the minimum volume and the maximum volume provides a substantially constant rate of fluid delivery and wherein the connection between the holding reservoir and the delivery reservoir permits flow only from the holding reservoir to the delivery reservoir while the pressure within the delivery reservoir is less than a maximum pressure, said connection having a relief chamber for receiving and accommodating fluid upon the pressure within the delivery reservoir attaining said maximum pressure.

15. An implantable drug delivery device as claimed in claim 14 wherein the control means comprises a first valve between the holding reservoir and the pump and a second valve between the pump and the delivery reservoir, said first and second valve permitting unidirectional flow to the pump and the delivery reservoir respectively, while said delivery reservoir is not filled to its maximum volume and the pressure within the delivery reservoir is below the maximum pressure, the second valve permitting flow to the holding reservoir while the pressure within said delivery reservoir is at least equal to the maximum pressure.

16. A drug delivery device as claimed in claim 14 wherein the control means comprises a one-way first valve between the holding reservoir and the pump, said relief chamber being located between the pump and the delivery reservoir, said relief chamber having a wall with an expandable portion and being resiliently expandable with the expandable portion of the wall of the relief chamber having a higher modulus of elasticity than the delivery reservoir whereby the expandable portion will expand on the pressure between the pump and delivery reservoir being at least equal to the maximum pressure.

17. A drug delivery device as claimed in claim 16 wherein a second one-way valve is mounted between the relief chamber and the delivery reservoir.

18. A drug delivery device as claimed in claim 14 wherein the flow restriction is provided with a plurality of flow pathways.

19. A drug delivery device as claimed in claim 18 wherein the flow restriction comprises a plurality of capillary passageways.

20. A drug delivery device as claimed in claim 18 wherein the flow restriction comprises a porous element.

21. A drug delivery device as claimed in claim 20 wherein the porous element is formed of glass, ceramic or like inert material.

22. A drug delivery device as claimed in claim 14 wherein the flow restriction comprises a single passageway and a filter located upstream from the passageway.

23. A drug delivery device as claimed in claim 14 wherein the delivery reservoir is enclosed by an enclosure having non-expandable walls to prevent the expansion of the delivery reservoir beyond the maximum volume.

24. A drug delivery device as claimed in claim 23 wherein the walls of the enclosure are rigid.

25. A drug delivery device as claimed in claim 23 wherein the walls of the enclosure are flexible.

26. A drug delivery device as claimed in claim 14 wherein the walls of the delivery reservoir are adapted to be incapable of expansion beyond the maximum volume.

27. A drug delivery device as claimed in claim 14 wherein the minimum volume comprises a volume of the delivery reservoir between the maximum volume and a reservoir minimum volume.