Use of salicylic acid for regulating skin wrinkles and/or skin atrophy

• US 5,872,112 A
• Filed: 10/21/1997
• Issued: 02/16/1999
• Est. Priority Date: 11/25/1991
• Status: Expired due to Term

• Current Assignee: The Procter & Gamble Company
• Original Assignee: Richardson-Vicks, Inc. (The Procter & Gamble Company)
• Inventors: Blank, Roy Lonnie
• Primary Examiner(s): Dodson, Shelley A.
• Application Number:
  US08/955,026
• Time in Patent Office: 483 Days
• Field of Search: 424/59, 424/60, 424/400, 424/401, 514/159, 514/844, 514/847, 514/887
• US Class Current: 514/159
• CPC Class Codes: A61K 31/60 Salicylic acid; Derivatives thereof
• CPC Class Codes: A61K 8/0208 Tissues; Wipes; Patches
• CPC Class Codes: A61K 8/35 Ketones, e.g. benzophenone
• CPC Class Codes: A61K 8/368 with carboxyl groups directly bound to carbon atoms of aromatic rings
• CPC Class Codes: A61K 8/37 Esters of carboxylic acids
• CPC Class Codes: A61K 8/40 containing nitrogen quinones containing nitrogen A61K8/355
• CPC Class Codes: A61K 8/445 aromatic, i.e. the carboxylic acid directly linked to the aromatic ring
• CPC Class Codes: A61K 8/671 Vitamin A; Derivatives thereof, e.g. ester of vitamin A acid, ester of retinol, retinol, retinal
• CPC Class Codes: A61K 8/8158 Homopolymers or copolymers of amides or imides, e.g. (meth) acrylamide; Compositions of derivatives of such polymers
• CPC Class Codes: A61P 17/16 Emollients or protectives, e.g. against radiation
• CPC Class Codes: A61Q 17/04 Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
• CPC Class Codes: A61Q 19/00 Preparations for care of the skin
• CPC Class Codes: A61Q 19/08 Anti-ageing preparations
• CPC Class Codes: A61Q 19/10 Washing or bathing preparations

Abstract

The present invention relates to a method for regulating wrinkles and/or atrophy in mammalian skin comprising treating the skin with a safe and effective amount of salicylic acid and/or additional active component.

Claims

1. A method for regulating wrinkles or atrophy in mammalian skin comprising treating the skin with a safe and effective amount of a composition comprising:

(a) a safe and effective amount of salicylic acid;

(b) a safe and effective amount of a penetration enhancing agent; and

(c) a pharmaceutically-acceptable carrier.

2. A method according to claim 1 wherein said penetration enhancing agent is selected from the group consisting of polyacrylamide, polyquaternium 32, and mixtures thereof.

3. The method of claim 1 wherein the composition comprises from about 0.01% to about 50% of salicylic acid.

4. The method of claim 1 wherein the composition comprises from about 0.1% to about 20% of salicylic acid.

5. The method of claim 1 wherein the composition comprises from about 0.2% to about 5% of salicylic acid.

6. The method of claim 1 wherein the composition comprises from about 1% to about 5% of salicylic acid.

7. The method of claim 1 wherein the composition comprises about 2% of salicylic acid.

8. The method of claim 3 wherein the pharmaceutically-acceptable carrier is a topical carrier.

9. The method of claim 8 wherein the carrier comprises water.

10. The method of claim 9 wherein the carrier comprises a hydroalcoholic solvent.

11. The method of claim 10 wherein the carrier comprises water and an alcohol selected from the group consisting of ethanol, isopropanol and mixtures thereof.

12. The method of claim 9 wherein the treatment of the skin with the composition is chronic.

13. The method of claim 12 wherein the treatment of the skin with the composition is for a period of at least about three weeks comprising application of the composition from about once per week to about two times daily.

14. The method of claim 1 wherein the composition has a pH of from about 2 to about 4.

15. The method of claim 1 wherein the composition has a pH of from about 2 to about 3.5.

16. The method of claim 9 wherein the composition has a pH of from about 2 to about 4.

17. The method of claim 9 wherein the composition has a pH of from about 2 to about 3.5.

18. The method of claim 16 wherein the composition comprises from about 0.2% to about 5% of salicylic acid.

19. The method of claim 16 wherein the composition comprises from about 1% to about 5% of salicylic acid.

20. The method of claim 16 wherein the composition comprises about 2% of salicylic acid.

21. The method of claim 1 wherein the composition comprises from about 1% to about 5% of the penetration enhancing agent.

22. The method of claim 19 wherein said penetration enhancing agent is selected from the group consisting of polyacrylamide, polyquaternium 32, and mixtures thereof.