Handheld electromonitor device

• US 5,873,990 A
• Filed: 08/21/1996
• Issued: 02/23/1999
• Est. Priority Date: 08/22/1995
• Status: Expired due to Term

• Current Assignee: ESA Biosciences, Inc. (Thermo Fisher Scientific Incorporated)
• Original Assignee: Andcare Incorporated
• Inventors: Henkens, Robert W., O'Daly, John P., Naser, Najih A., Ebeling, Frederick A., Wegner, Steven E., Wojciechowski, Marek
• Primary Examiner(s): Warden, Robert
• Assistant Examiner(s): NOGUEROLA, ALEXANDER STEPHAN
• Application Number:
  US08/711,186
• Time in Patent Office: 916 Days
• Field of Search: 324/439, 324/445, 324/446, 324/450, 204/400, 204/406, 204/407, 204/403, 205/775, 205/779, 205/780, 205/789
• US Class Current: 204/406
• CPC Class Codes: G01N 33/48714 for determining substances foreign to the organism, e.g. drugs or heavy metals drugs by chemical analysis G01N33/94
• CPC Class Codes: G01N 35/00732 Identification of carriers, materials or components in automatic analysers

Abstract

An apparatus is disclosed which is a microprocessor based instrument designed to conveniently and rapidly measure various analytes in environmental and biological samples. The instrument operates as a stand-alone unit powered by a battery or a DC power module and may be equipped with a communication port allowing uploading test results to a computer. Several unique electronic, microchip and software configurations were developed for the device to make it a portable, low-cost, safe, automated and simple-to-operate instrument particularly adapted for precise and accurate measurement of metal ions such as heavy metals such as lead in human blood.

Claims

1. Apparatus for measuring the amount of an analyte in a liquid electrolyte which comprises:

a housing substantially enclosing a data processing system including a power supply, a microprocessor, and a memory;

a sensor insertable in the housing and comprising a colloidal gold working electrode, a reference electrode and a counter electrode adapted to be in contact with a sample of said electrolyte;

an electrical connector adapted to couple signal output from the inserted sensor with the data processing system;

a microchip positioned outside the housing and containing calibration data interrelating values of said signal output with amounts of said analyte in said electrolyte;

a microchip reader on the housing operable to transfer calibration data from the microchip to the data processing system;

circuitry within the housing configured to apply a square wave coulometric analytical technique to the sensor;

a source of potential within the housing adapted to apply a potential to said circuitry; and

wherein

said microprocessor is programmed to apply said potential to said circuitry to measure the signal output from the sensor, and to compare said measured output signal with said calibration data to thereby determine the amount of said analyte in said electrolyte.

2. The apparatus of claim 3 wherein the microchip comprises a look up table.

3. The apparatus of claim 1 further comprising a structural module attached to said housing and configured to screen said sensor from drafts.

4. The apparatus of claim wherein the structural module includes a metal plate extending from the housing to support the sensor and serve as a heat sink for the sensor.

5. An apparatus for analyzing a metal analyte, comprising:

a colloidal gold sensor adapted at one end to be mechanically coupled to a housing and at another end contacted with a sample to be analyzed for the metal analyte, said another end including a counter-electrode; and

,

a microprocessor in the housing;

a) adapted to apply a sequence of potential steps to the colloidal gold electrode sufficient to cause said sensor to generate and transmit current to a data processing system through the housing;

b) adapted to communicate with a source of calibration data positioned outside the housing in a manner that will correlate current values generated and transmitted by the sensor for different amounts of said electrolyte in the sample; and

c) programmed to compare currents generated and transmitted by the sensor in response to the potentials with the calibration data to thereby ascertain the amount of the analyte in the sample.