Enantiomerically pure 2-aminopurine phosphonate nucleotide analogs as antiviral agents
First Claim
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1. A compound having the structural formula (A) ##STR15## in enantiomerically pure form, wherein:
- R is selected from the group consisting of;
##STR16## in which R1 and R2 are independently selected from the group consisting of hydrogen and lower alkyl, R3 is lower alkyl or --(CH2)n --C6 H5, and n is an integer in the range of 0 to 6 inclusive;
R'"'"' is selected from the group consisting of hydrogen, hydroxyl, carboxyl, alkoxy, amino and halogen; and
R" is hydrogen or a halogen substituent,or a pharmaceutically acceptable salt or ester thereof.
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Abstract
Cyclic and acyclic 2-aminopurine phosphonate nucleotide analogs useful to treat herpes viral infections are provided in enantiomerically pure form. Pharmaceutical compositions and methods for treating herpes viral infections are provided as well, as is a chiral synthesis for preparing the novel compounds in enantiomerically pure form.
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24 Claims
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1. A compound having the structural formula (A) ##STR15## in enantiomerically pure form, wherein:
- R is selected from the group consisting of;
##STR16## in which R1 and R2 are independently selected from the group consisting of hydrogen and lower alkyl, R3 is lower alkyl or --(CH2)n --C6 H5, and n is an integer in the range of 0 to 6 inclusive;R'"'"' is selected from the group consisting of hydrogen, hydroxyl, carboxyl, alkoxy, amino and halogen; and R" is hydrogen or a halogen substituent, or a pharmaceutically acceptable salt or ester thereof. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23)
- R is selected from the group consisting of;
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24. A compound having the structural formula (A) ##STR25## in enantiomerically pure form, wherein:
- R is selected from the group consisting of ##STR26## in which R1 and R2 are independently selected from the group consisting of hydrogen and lower alkyl, R3 is lower alkyl or --(CH2)n --C6 H5, and n is an integer in the range of 0 to 6 inclusive;
R'"'"' is selected from the group consisting of hydrogen, hydroxyl, carboxyl, alkoxy, amino and halogen; and R" is hydrogen, or a pharmaceutically acceptable salt or ester thereof.
- R is selected from the group consisting of ##STR26## in which R1 and R2 are independently selected from the group consisting of hydrogen and lower alkyl, R3 is lower alkyl or --(CH2)n --C6 H5, and n is an integer in the range of 0 to 6 inclusive;
Specification