Drug infusion catheter and method

• US 5,882,332 A
• Filed: 06/06/1997
• Issued: 03/16/1999
• Est. Priority Date: 06/06/1997
• Status: Expired due to Fees

• Current Assignee: Bandula Wijay
• Original Assignee: Bandula Wijay
• Inventors: Wijay, Bandula
• Primary Examiner(s): Yasko, John D.
• Assistant Examiner(s): Blyveis, Deborah
• Application Number:
  US08/870,562
• Time in Patent Office: 648 Days
• Field of Search: 604/264, 604/280, 604/49, 604/52, 604/53, 604/22, 604/93, 600/568, 600/571, 600/572, 606/159
• US Class Current: 604/508
• CPC Class Codes: A61M 2025/0057 Catheters delivering medicament other than through a conventional lumen, e.g. porous walls or hydrogel coatings
• CPC Class Codes: A61M 2025/0073 Tip designed for influencing the flow or the flow velocity of the fluid, e.g. inserts for twisted or vortex flow general flow characteristics A61M2206/10
• CPC Class Codes: A61M 2025/09183 having tools at the distal tip
• CPC Class Codes: A61M 2025/1047 having centering means, e.g. balloons having an appropriate shape
• CPC Class Codes: A61M 25/00 Catheters; Hollow probes dilators A61M29/00; peritoneal catheters A61M1/285; tracheal tubes A61M16/04; for drainage A61M27/00; for uterus, vagina or rectum A61M31/00 ; for measuring or testing A61B; materials for catheters A61L29/00
• CPC Class Codes: A61M 25/0043 characterised by structural features
• CPC Class Codes: A61M 25/0068 Static characteristics of the catheter tip, e.g. shape, atraumatic tip, curved tip or tip structure
• CPC Class Codes: A61M 25/0074 Dynamic characteristics of the catheter tip, e.g. openable, closable, expandable or deformable
• CPC Class Codes: A61M 25/008 Strength or flexibility characteristics of the catheter tip
• CPC Class Codes: A61M 29/02 Dilators made of swellable material balloon catheters for angioplasty A61M25/104

Abstract

A method and apparatus of delivery of a drug (or substance) is disclosed which involves (1) injecting a drug into the tissue of the blood vessel; (2) maintaining the delivery system as symmetrical as possible in tortuous blood vessels, and (3) providing a preferably constant flow of blood during the drug treatment.

Claims

1. A fluid infusion catheter for use in a blood vessel defined by a wall, comprising:

an elongated tubular body having a proximal and a distal end and an outer surface and defining a passage therein;

at least one flexible bristle fixedly mounted adjacent said outer surface of said body;

said bristle having a proximal and a distal end and a passage therethrough in flow communication with said passage in said body so that a fluid can be directed through said body and said bristle and to the vessel wall without occlusion of the vessel.

2. The catheter of claim 1, wherein:

said body further comprises a sheath to retain said bristle in a retracted position, said sheath being retractable from over said bristle to allow it to extend toward the vessel wall.

3. The catheter of claim 2, wherein:

said bristle, when extended, and said body further comprise longitudinal axes which intersect.

4. The catheter of claim 3, wherein:

said bristle further comprises a plurality of radiating bristles in a single plane which defines a row of said bristles.

5. The catheter of claim 4, wherein:

said row further comprises a plurality of rows of said bristles.

6. The catheter of claim 5, further comprising:

a bend on said distal end of a plurality of said bristles such that upon retraction of said sheath, said distal end of said bristles is in substantial alignment with the vessel wall.

7. The catheter of claim 6, wherein:

said body further comprises a radiation material;

said sheath comprises a shield for said radiation material.

8. The catheter of claim 5, wherein:

said bristles are of a predetermined length such that upon retraction of said sheath, said distal end of said bristles flexes to a position in close proximity to the vessel wall.

9. The catheter of claim 8, wherein:

said bristles upon flexing are in contact with the vessel wall.

10. The catheter of claim 9, wherein:

said bristles are externally tapered down from said proximal end of said bristles adjacent said body to said distal end of said bristles.

11. The catheter of claim 10, wherein:

said radiating bristles act to centralize said body in the vessel.

12. The catheter of claim 11, wherein:

said body comprises an outer tube surrounding an inner tube defining an annulus therebetween which serves as said passage;

said passage in said bristles is in flow communication with said annulus for delivery of fluid under pressure to the vessel wall.

13. The catheter of claim 12, wherein:

said inner tube has a passage therethrough which can accept a guidewire for advancement of the catheter.

14. The catheter of claim 2, wherein:

said bristle is of a predetermined length such that upon retraction of said sheath, said distal end of said bristle flexes to a position in close proximity to the vessel wall.

15. The catheter of claim 14, wherein:

said bristle upon flexing is in contact with the vessel wall.

16. The catheter of claim 2, wherein:

said bristle is externally tapered down from said proximal end of said bristle adjacent said body to said distal end of said bristle.

17. The catheter of claim 4, wherein:

said radiating bristles act to centralize said body in the vessel.

18. The catheter of claim 1, wherein:

said body comprises an outer tube surrounding an inner tube defining an annulus therebetween which serves as said passage;

said passage in said bristle is in flow communication with said annulus for delivery of fluid under pressure to the vessel wall.

19. The catheter of claim 18, wherein:

said inner tube has a passage therethrough which can accept a guidewire for advancement of the catheter.

20. A method of treating a vessel defined by a wall with a fluid without occlusion thereof, comprising:

mounting at least one flexible bristle adjacent the outer surface of an elongated body of a catheter;

inserting into a vessel said catheter having said elongated body with a passage in flow communication with said bristle with a passage therethrough;

retaining said bristle in a flexed state adjacent said outer surface of said elongated body during said inserting;

allowing said bristle to flex toward the vessel wall at a predetermined location;

pumping fluid through said passages in said body and bristle and against the vessel wall while blood flows around said body and bristle.

21. The method of claim 20, further comprising:

retaining said bristle with a movable sheath.

22. The method of claim 21, further comprising:

using a plurality of rows of bristles extending from said body;

allowing said bristles to flex to close proximity with the vessel wall upon retraction of said sheath.

23. A method of treating a vessel with a radiation source, comprising:

providing a source on a catheter body having an outer surface;

providing a plurality of bristles having a proximal and a distal end, said bristles being fixedly mounted adjacent said outer surface of said body;

providing a movable sheath over said body which shields said source and holds said bristles in a retracted position;

advancing said body with said source while said source is covered by said sheath to a predetermined location in a vessel;

exposing said bristles and said source by retraction of said sheath;

allowing said bristles to extend toward the vessel wall;

centralizing said source in the vessel with said bristles.

24. The method of claim 23, further comprising:

providing a bend on said distal end of a plurality of said bristles;

placing said distal end in substantial alignment with the vessel wall as a result of retraction of said sheath.

25. The method of claim 24, further comprising:

providing a passage through said body and said bristles to allow fluid to be pumped therethrough.

26. The method of claim 24, further comprising:

allowing blood to flow around said bristles when in contact with the vessel.

27. A fluid infusion catheter for use in a blood vessel defined by a wall, comprising:

an elongated tubular body having a proximal and a distal end and an outer surface and defining a passage therein;

at least one flexible bristle having a passage therethrough in flow communication with said passage in said body so that a fluid can be directed through said body and said bristle and to the vessel wall without occlusion of the vessel;

said bristle is selectively retained adjacent said outer surface of said body.

28. A method of treating a vessel defined by a wall with a fluid without occlusion thereof, comprising:

inserting into a vessel a catheter having an elongated body with a passage in flow communication with at least one flexible bristle with a passage therethrough;

retaining said bristle in a retracted state with a movable sheath during said inserting;

allowing said bristle to flex toward the vessel wall at a predetermined location;

pumping a fluid through said passages in said body and bristle and against the vessel wall while blood flows around said body and bristle;

using a plurality of bristles which, upon retraction of said sheath from said body, flex to extend radially in contact with said wall to centralize said body in the vessel.

29. A method of treating a vessel defined by a wall with a fluid without occlusion thereof, comprising:

inserting into a vessel a catheter having an elongated body;

using concentric tubes to create an annular passage in said body with said annular passage in flow communication with a plurality of bristles with a passage therethrough;

advancing said concentric tubes over a guidewire;

using said bristles to close off an end of said annular passage;

providing a taper on said bristles;

using a plurality of rows of bristles extending from said body;

retaining said bristles in a retracted state with a movable sheath during said inserting;

allowing said bristles to flex toward the vessel wall at a predetermined location upon retraction of said sheath;

allowing said bristles to contact the vessel upon retraction of said sheath,

pumping fluid through said annular passage in said body and said bristles and against the vessel wall while blood flows around said body and bristles.