Close vascularization implant material

• US 5,882,354 A
• Filed: 06/07/1995
• Issued: 03/16/1999
• Est. Priority Date: 10/31/1990
• Status: Expired due to Term

• Current Assignee: Baxalta GmbH (Shire plc), Baxalta Incorporated (Shire plc)
• Original Assignee: Baxter International Inc.
• Inventors: Martinson, Laura A., Johnson, Robert C., Brauker, James H., Hill, Ronald S.
• Primary Examiner(s): Weiss, John G.
• Assistant Examiner(s): CUDDIHY, FRANCIS KEVIN
• Application Number:
  US08/480,198
• Time in Patent Office: 1,378 Days
• Field of Search: 424/422-425, 623/1-3, 623/10-12, 623/16, 623/18, 623/66, 435/284, 435/240.241
• US Class Current: 424/423
• CPC Class Codes: A61B 5/14532 for measuring glucose, e.g. by tissue impedance measurement
• CPC Class Codes: A61B 5/413 Monitoring transplanted tissue or organ, e.g. for possible rejection reactions after a transplant
• CPC Class Codes: A61F 2/022 Artificial gland structures using bioreactors hemodialysis A61M1/16; hemofiltration A61M1/34; other extracorporeal blood treatment A61M1/36
• CPC Class Codes: A61L 27/38 containing added animal cells organs or tissue containing native cells A61L27/36
• CPC Class Codes: A61L 27/3839 characterised by the site of application in the body materials for artificial blood vessels A61L27/507; materials for use in artificial skin A61L27/60
• CPC Class Codes: A61L 27/56 Porous materials, e.g. foams or sponges
• CPC Class Codes: A61L 29/005 Ingredients of undetermined constitution or reaction products thereof
• CPC Class Codes: A61L 29/085 Macromolecular materials
• CPC Class Codes: A61L 29/146 Porous materials, e.g. foams or sponges
• CPC Class Codes: Y10S 623/92 Method or apparatus for preparing or treating prosthetic
• CPC Class Codes: Y10S 623/925 Natural

Abstract

A device for implantation in a host having a material at an interface between the host and the device, said material having a conformation which results in growth of vascular structures by the host close to the interface.

Claims

1. A device having a wall defining a chamber for holding living cells for implanting into a mammalian host wherein the wall comprises:

(a) a second zone of a material defining a chamber wherein the material is permeable to the flow of nutrients from the host to living cells and products from the living cells to the host and impermeable to host immune cells; and

(b) a first zone of porous material outside of the second zone of material having a nominal pore size from about 0.6 to about 20 microns which comprises frames of elongated strands of material that are less than 5 microns in all but the longest dimension wherein said frames define apertures which interconnect to form three-dimensional cavities which permit substantially all inflammatory cells migrating into the cavities to maintain a rounded morphology, wherein the first zone promotes vascularization adjacent but not substantially into the first zone upon implantation into the host, and wherein the porous material is selected from the group consisting of polyethylene, polypropylene, polytetrafluoroethylene (PTFE), cellulose acetate, cellulose nitrate, polycarbonate, polyester, nylon, polysulfone, mixed esters of cellulose, polyvinylidene difluoride, silicone, and polyacrylonitrile.

5. The device according to claims 1 or 2, wherein said second zone is further impermeable to immune factors.

2. A device having a wall defining a chamber for holding living cells for implanting into a mammalian host wherein the wall comprises:

(a) a second zone defining a chamber which is permeable to the flow of nutrients from the host to cells and products from the cells to the host and impermeable to host immune cells; and

(b) a first zone outside of the second zone which comprises frames of elongated strands of material that are less than 5 microns in all but the longest dimension wherein said frames define apertures which interconnect to form three-dimensional cavities with interconnected apertures which permit substantially all inflammatory cells migrating into the cavities to maintain a rounded morphology, and wherein the first zone promotes vascularization adjacent but not substantially into the first zone upon implantation into the host.

3. The device according to claim 2, wherein the second zone comprises a porous material selected from the group consisting of polyethylene, polypropylene, polytetrafluoroethylene (PTFE), cellulose acetate, cellulose nitrate, polycarbonate, polyester, nylon, polysulfone, mixed esters of cellulose, polyvinylidene difluoride, silicone, and polyacrylonitrile.

4. The device according to claim 3, wherein the second zone comprises porous material having a nominal porous size about 0.6 to about 20 microns.