Form of paroxetine hydrochloride anhydrate

CAFC
  • US 5,900,423 A
  • Filed: 09/02/1997
  • Issued: 05/04/1999
  • Est. Priority Date: 02/06/1995
  • Status: Expired due to Term
First Claim
Patent Images

1. Paroxetine hydrochloride anhydrate in Form A, which form comprises the following characteristics:

  • a melting point of about 123-125°

    C.;

    IR bands at about 513, 538, 571, 592, 613, 665, 722, 761, 783, 806, 818, 839, 888, 906, 924, 947, 966, 982, 1006, 1034, 1068, 1091, 1134, 1194, 1221, 1248, 1286, 1340, 1387, 1493, 1513, 1562, 1604, 3402, and 3631 cm-1 ;

    maximum endotherm, measured at 10°

    C. per minute, of about 126°

    C. in an open pan and about 121°

    C. in a closed pan;

    characteristic X-ray diffractogram peaks at about 6.6, 8.0, 11.2, and 13.1 degrees 2 theta;

    characteristic solid state 13 C-NMR spectrum peaks at about 154.3, 149.3, 141.6, and 138.5 ppm.

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