Pulse oximeter with sigma-delta converter

• US 5,921,921 A
• Filed: 12/18/1996
• Issued: 07/13/1999
• Est. Priority Date: 12/18/1996
• Status: Expired due to Term

• Current Assignee: Nellcor Puritan-Bennett
• Original Assignee: Nellcor Puritan-Bennett
• Inventors: Nootbaar, Michael W., Potratz, Robert Stephen
• Primary Examiner(s): O'Connor, Cary
• Assistant Examiner(s): WINAKUR, ERIC FRANK
• Application Number:
  US08/769,148
• Time in Patent Office: 937 Days
• Field of Search: 600/322, 600/323, 600/330, 600/324, 600/336, 356/41, 341/143
• US Class Current: 600/323
• CPC Class Codes: A61B 5/14551 for measuring blood gases

Abstract

A preferred oximeter detects the transillumination by red and infrared light of a portion of an in vivo subject and produces analog signals representative thereof on two channels. Sigma-delta modulators sample the analog signals on each channel. A digital filter processor digitally filters the sample signals from both modulators to produce respective digital signals with multi-bit resolution.

Claims

1. An oximeter apparatus comprising:

sensor means for producing first and second analog signals respectively representative of the transillumination of a body portion of an in vivo subject by respective first and second wavelengths of radiation;

converter means for receiving and converting said first and second analog signals into respective first and second digital signals; and

signal processing means for receiving and processing said first and second digital signals for determining blood oxygen saturation of the subject,

said converter means including

a first sigma-delta modulator for receiving said first analog signal and for producing a first sample signal representative thereof,

a second sigma-delta modulator for receiving said second analog signal and for producing a second sample signal representative thereof, and

a digital filter processor having means for receiving both of said first and second sample signals and responsive thereto for digitally filtering said sample signals in order to produce said respective first and second digital signals,

said digital filter processor including programming for digitally filtering said sample signals in order to produce said first and second digital signals, and for controlling the input sampling rate from said modulators and controlling the filter corner frequency and output update rate of said first and second digital signals.

2. The apparatus as set forth in claim 1, said digital filter processor including means for successive decimation filtering of said sample signals.

3. The apparatus as set forth in claim 1, said digital filter processor including means for producing said first and second digital signals representative of said first and second analog signals with at least seventeen bit resolution respectively.

4. The apparatus as set forth in claim 1, said digital filter processor including a microprocessor.

5. The apparatus as set forth in claim 1, said modulators including over-sampling modulators.

6. The apparatus as set forth in claim 1, said modulators including second order modulators.

7. The apparatus as set forth in claim 1, said modulators including second order, over-sampling modulators, said digital filter processor including means for successive decimation filtering of said sample signals, said digital filter processor including means for producing said first and second digital signals representative of said first and second analog signals with at least seventeen bit resolution, said digital filter processor including a microprocessor.

8. The apparatus as set forth in claim 1, said digital filter processor including means for sampling at a rate of about 4.8 KHz and performing six stages of decimation filtering to produce an update rate of about 78 samples per second.

9. The apparatus as set forth in claim 1, said sensor means disposed in a probe having means for coupling said probe with said apparatus.

10. The apparatus as set forth in claim 1, said sensor means including a probe including

first light emitting means for emitting light of said first wavelength having a first known wavelength value,

light sensing means for sensing the light emitted by said first light emitting means, and

encoding means for providing encoded signals indicative of at least said first known wavelength value.

11. The apparatus as set forth in claim 10 further including

a second light emitting means for emitting light of said second wavelength having a second known wavelength value,

said light sensing means including the means for sensing the light emitted from said second light emitting means,

said encoding means including means for providing encoded signals indicative of at least said second known wavelength value.

12. The apparatus as set forth in claim 10, said encoding means including an electrical impedance element, the value of which is selected to correlate with said known wavelength value.

13. The apparatus as set forth in claim 12, said electrical impedance element including a resistor.

14. The apparatus as set forth in claim 13, said encoded signals including voltage signals produced by passing a current through said resistor.

15. The apparatus as set forth in claim 1, said sensor means including a non-invasive, electro-optical sensor probe configured for disposition onto a surface of the subject.

16. The apparatus as set forth in claim 15, said sensor probe being configured for flexibly conforming to the surface of the subject.

17. The apparatus as set forth in claim 15, said sensor probe being configured for removable disposition onto the surface of the subject.

18. The apparatus as set forth in claim 1, said wavelengths falling respectively in the infrared and red regions.

19. The apparatus as set forth in claim 1, said sensor means including first and second light emitting diodes for producing said first and second wavelengths of light, respectively.

20. The apparatus as set forth in claim 1, said converter means including gain adjusting means for adjusting the gains of said modulators in response to variations in said first and second analog signals.

21. The apparatus as set forth in claim 20, said adjusting means including programming within said digital filter processor for controlling the operation thereof.

22. The apparatus as set forth in claim 20, said converter means including signal amplifiers for amplifying said first and second analog signals, said gain adjusting means including means for adjusting the gain of said amplifiers.

23. The apparatus as set forth in claim 20, said converter means including means for providing feedback from said digital filter processor to said modulators, said gain adjusting means including feedback adjusting means for selectively adjusting said feedback in order to selectively adjust the gains of said modulators.

24. The apparatus as set forth in claim 23, said feedback adjusting means including programming in said digital filter processor for controlling the operation thereof.

25. An oximeter apparatus comprising:

sensor means for producing first and second analog signals respectively representative of the transillumination of a body portion of an in vivo subject by respective first and second wavelengths of radiation;

converter means for receiving and converting said first and second analog signals into respective first and second digital signals; and

signal processing means for receiving and processing said first and second digital signals for determining blood oxygen saturation of the subject,

said converter means including

a first sigma-delta modulator for receiving said first analog signal and for producing a first sample signal representative thereof,

a second sigma-delta modulator for receiving said second analog signal and for producing a second sample signal representative thereof, and

a digital filter processor having means for receiving both of said first and second sample signals and responsive thereto for digitally filtering said sample signals in order to produce said respective first and second digital signals,

said converter means including gain adjusting means for adjusting the gains of said modulators in response to variations in said first and second analog signals,

said adjusting means including programming within said digital filter processor,

said converter means including signal amplifiers for amplifying said first and second analog signals, said gain adjusting means including switching means for selectively switching resistance in connection with said amplifiers for adjusting the gains thereof.

26. The apparatus as set forth in claim 25, said adjusting means including programming within said digital processor operable for controlling said switching means.

27. An oximeter apparatus comprising:

sensor means for producing first and second analog signals respectively representative of the transillumination of a body portion of an in vivo subject by respective first and second wavelengths of radiation;

converter means for receiving and converting said first and second analog signals into respective first and second digital signals; and

signal processing means for receiving and processing said first and second digital signals for determining blood oxygen saturation of the subject,

said converter means including

a first sigma-delta modulator for receiving said first analog signal and for producing a first sample signal representative thereof,

a second sigma-delta modulator for receiving said second analog signal and for producing a second sample signal representative thereof, and

a digital filter processor having means for receiving both of said first and second sample signals and responsive thereto for digitally filtering said sample signals in order to produce said respective first and second digital signals,

said converter means including gain adjusting means for adjusting the gains of said modulators in response to variations in said first and second analog signals,

said first and second analog signals including respective first and second current signals, said converter means including means connecting said first and second current signals directly to amplifiers of said first and second sigma-delta modulators respectively without current to voltage conversion of said current signals.

28. The apparatus as set forth in claim 27, said converter means including gain adjusting means for adjusting the gains of said modulators in response to variations in said first and second analog signals.

29. The apparatus as set forth in claim 28, said converter means including feedback means for providing feedback signals in the nature of square waves having respective pulse widths as feedback from said digital filter processor to said modulators, said gain adjusting means including means for selectively adjusting said pulse widths in order to selectively adjust the gains of said modulators.

30. The apparatus as set forth in claim 29, said feedback means including programming in said digital filter processor for controlling the operation thereof.

31. The apparatus as set forth in claim 28, said converter means including current sources connected with said modulators in a configuration for interacting with said current signals, said gain adjusting means including means for selectively switching said current sources in order to adjust the gains of said modulators.

32. An oximeter apparatus comprising:

sensor means for producing first and second analog signals respectively representative of the transillumination of a body portion of an in vivo subject by respective first and second wavelengths of radiation;

converter means for receiving and converting said first and second analog signals into respective first and second digital signals; and

signal processing means for receiving and processing said first and second digital signals for determining blood oxygen saturation of the subject,

said converter means including

a first sigma-delta modulator for receiving said first analog signal and for producing a first sample signal representative thereof,

a second sigma-delta modulator for receiving said second analog signal and for producing a second sample signal representative thereof, and

a digital filter processor having means for receiving both of said first and second sample signals and responsive thereto for digitally filtering said sample signals in order to produce said respective first and second digital signals,

said converter means including gain adjusting means for adjusting the gains of said modulators in response to variations in said first and second analog signals,

said modulators including respective ground sensing amplifiers as first integrators and second integrators biased to a reference voltage between ground and supply voltage, said supply voltage being no greater than about +5 V.

33. An oximeter apparatus comprising:

sensor means for producing first and second analog signals respectively representative of the transillumination of a body portion of an in vivo subject by respective first and second wavelengths of radiation;

converter means for receiving and converting said first and second analog signals into respective first and second digital signals; and

signal processing means for receiving and processing said first and second digital signals for determining a blood oxygen saturation of the subject,

said converter means including

a first sigma-delta modulator for receiving said first analog signal and for producing a first sample signal representative thereof,

a second sigma-delta modulator for receiving said second analog signal and for producing a second sample signal representative thereof, and

a digital filter processor having means for receiving both of said first and second sample signals and responsive thereto for digitally filtering said sample signals in order to produce said respective first and second digital signals, said oximeter further including

first and second light emitting diodes for producing said respective first and second wavelengths,

a drive circuit for selectively activating said diodes, and

deactivating means for determining the occurrence of a short circuit connected to said diodes and responsive thereto for deactivating said diodes.

34. An oximeter apparatus comprising:

sensor means for producing first and second analog signals respectively representative of the transillumination of a body portion of an in vivo subject by respective first and second wavelengths of radiation;

converter means for receiving and converting said first and second analog signals into respective first and second digital signals; and

signal processing means for receiving and processing said first and second digital signals for determining blood oxygen saturation of the subject,

said converter means including

a first sigma-delta modulator for receiving said first analog signal and for producing a first sample signal representative thereof,

a second sigma-delta modulator for receiving said second analog signal and for producing a second sample signal representative thereof, and

a digital filter processor having means for receiving both of said first and second sample signals and responsive thereto for digitally filtering said sample signals in order to produce said respective first and second digital signals,

said sensor means including

a detachable probe configured for disposition onto a surface of a subject, said probe having first and second light emitting diodes for producing said first and second wavelengths of light respectively in the red and infrared bands and having a photo detector for producing said first and second analog signals,

a drive circuit having means for selectively activating said diodes, and

encoding means for providing analog encoded signals indicative of the wavelengths of light emitted by said diodes and including an impedance element included as part of said probe and operable for producing a voltage as said analog encoded signals,

said apparatus further including a third sigma-delta modulator having means for receiving said analog encoded signals and for producing a third sample signal representative thereof,

said digital signal filter processor having means for receiving said third sample signal and responsive thereto for digitally filtering said third sample signal for producing a digital encoded signal,

said signal processing means including means for receiving and processing said digital encoded signal for use in calibrating said apparatus.

35. A method of determining the blood oxygen saturation of an in vivo subject comprising the steps of:

(a) producing first and second analog signals respectively representative of the transillumination of a body portion of the subject by respective first and second wavelengths of light;

(b) converting said first and second analog signals into respective first and second digital signals; and

(c) processing said first and second digital signals for determining the blood oxygen saturation of the subject,

step (b) further including the steps of

using a first sigma-delta modulator for receiving said first analog signal and for producing a first sample signal representative thereof,

using a second sigma-delta modulator for receiving said second analog signal and for producing a second sample signal representative thereof, and

providing both of said first and second sample signals to a digital filter processor and therein digitally filtering said sample signals in order to produce said respective first and second digital signals,

step (b) further including the steps of using programming in said digital filter processor for digitally filtering said sample signals in order to produce said first and second digital signals, and for controlling the input sampling rate from said modulators and controlling the filter corner frequency and output update rate of said first and second digital signals.

36. The method as set forth in claim 35, step (b) including the step of using second order, over-sampling modulators as said modulators.

37. The method as set forth in claim 35, step (b) including the step of performing successive decimation filtering of said sample signals.

38. The method as set forth in claim 35, step (b) including the step of producing said first and second digital signals representative of said first and second analog signals with at least seventeen bit resolution.

39. The method as set forth in claim 35, step (b) including the step of using a microprocessor as said digital filter processor.

40. The method as set forth in claim 35, step (b) including the step of using over-sampling modulators as said modulators.

41. The method as set forth in claim 40, step (b) including the step of using second order modulators as said modulators.

42. The method as set forth in claim 35, step (b) including sampling at a rate of about 4.8 KHz and performing six stages of decimation filtering to produce an update rate of about 78 samples per second.

43. The method as set forth in claim 35, step (b) further including the step of adjusting the gains of said modulators in response to variations in said first and second analog signals.

44. The method as set forth in claim 43, step (b) further including the step of using programming within said digital filter processor for said adjusting.

45. The method as set forth in claim 43, step (b) further including the step of using amplifiers for amplifying said first and second analog signals and selectively adjusting the gain of said amplifiers.

46. A method of determining the blood oxygen saturation of an in vivo subject comprising the steps of:

(a) producing first and second analog signals respectively representative of the transillumination of a body portion of the subject by respective first and second wavelengths of light;

(b) converting said first and second analog signals into respective first and second digital signals; and

(c) processing said first and second digital signals for determining the blood oxygen saturation of the subject,

step (b) further including the steps of

using a first sigma-delta modulator for receiving said first analog signal and for producing a first sample signal representative thereof,

using a second sigma-delta modulator for receiving said second analog signal and for producing a second sample signal representative thereof, and

providing both of said first and second sample signals to a digital filter processor and therein digitally filtering said sample signals in order to produce said respective first and second digital signals,

step (b) further including the step of adjusting the gains of said modulators in response to variations in said first and second analog signals,

step (b) further including the step of using amplifiers for amplifying said first and second analog signals and selectively adjusting the gain of said amplifiers, said method further including the step of selectively switching resistance in connection with said amplifiers for adjusting the gains thereof.

47. The method as set forth in claim 46, step (b) further including the step of using programming within said digital processor operable for controlling said switching.

48. A method of determining the blood oxygen saturation of an in vivo subject comprising the steps of:

(a) producing first and second analog signals respectively representative of the transillumination of a body portion of the subject by respective first and second wavelengths of light;

(b) converting said first and second analog signals into respective first and second digital signals; and

(c) processing said first and second digital signals for determining the blood oxygen saturation of the subject,

step (b) further including the steps of

using a first sigma-delta modulator for receiving said first analog signal and for producing a first sample signal representative thereof,

using a second sigma-delta modulator for receiving said second analog signal and for producing a second sample signal representative thereof, and

providing both of said first and second sample signals to a digital filter processor and therein digitally filtering said sample signals in order to produce said respective first and second digital signals,

step (b) further including the step of adjusting the gains of said modulators in response to variations in said first and second analog signals,

step (b) further including the step of providing feedback from said digital filter processor to said modulators and adjusting said feedback in order to selectively adjust the gains of said modulators.

49. The method as set forth in claim 48, step (b) further including the step of using programming in said digital filter processor for adjusting said feedback.

50. A method of determining the blood oxygen saturation of an in vivo subject comprising the steps of:

(a) producing first and second analog signals respectively representative of the transillumination of a body portion of the subject by respective first and second wavelengths of light;

(b) converting said first and second analog signals into respective first and second digital signals; and

(c) processing said first and second digital signals for determining the blood oxygen saturation of the subject,

step (b) further including the steps of

using a first sigma-delta modulator for receiving said first analog signal and for producing a first sample signal representative thereof,

using a second sigma-delta modulator for receiving said second analog signal and for producing a second sample signal representative thereof, and

providing both of said first and second sample signals to a digital filter processor and therein digitally filtering said sample signals in order to produce said respective first and second digital signals,

step (b) further including the step of adjusting the gains of said modulators in response to variations in said first and second analog signals,

said first and second analog signals including respective first and second current signals, step (b) further including the step of connecting said first and second current signals to amplifiers of said first and second sigma-delta modulators respectively without current to voltage conversion of said current signals.

51. The method as set forth in claim 50, step (b) further including the step of using current sources connected with said modulators in a configuration for interacting with said current signals and selectively switching said current sources in order to adjust the gains of said modulators.

52. The method as set forth in claim 50, said modulators including respective ground sensing amplifiers as first integrators and second integrators biased to a reference voltage between ground and supply voltage, step (b) further including the step of providing said supply voltage no greater than about +5 V.

53. A method of determining the blood oxygen saturation of an in vivo subject comprising the steps of:

(a producing first and second analog signals respectively representative of the transillumination of a body portion of the subject by respective first and second wavelengths of light;

(b converting said first and second analog signals into respective first and second digital signals; and

(c) processing said first and second digital signals for determining the blood oxygen saturation of the subject,

step (b) further including the steps of

using a first sigma-delta modulator for receiving said first analog signal and for producing a first sample signal representative thereof,

using a second sigma-delta modulator for receiving said second analog signal and for producing a second sample signal representative thereof, and

providing both of said first and second sample signals to a digital filter processor and therein digitally filtering said sample signals in order to produce said respective first and second digital signals,

step (b) further including the step of adjusting the gains of said modulators in response to variations in said first and second analog signals,

step (b) further including the step of providing feedback signals in the nature of square waves having respective pulse widths as feedback from said digital filter processor to said modulators, and selectively adjusting said pulse widths in order to selectively adjust the gains of said modulators.

54. The method as set forth in claim 53, step (b) further including the step of using programming in said digital filter processor for controlling said pulse widths.

55. A method of determining the blood oxygen saturation of an in vivo subject comprising the steps of:

(a) producing first and second analog signals respectively representative of the transillumination of a body portion of the subject by respective first and second wavelengths of light;

(b) converting said first and second analog signals into respective first and second digital signals; and

(c) processing said first and second digital signals for determining the blood oxygen saturation of the subject,

step (b) further including the steps of

using a first sigma-delta modulator for receiving said first analog signal and for producing a first sample signal representative thereof,

using a second sigma-delta modulator for receiving said second analog signal and for producing a second sample signal representative thereof, and

providing both of said first and second sample signals to a digital filter processor and therein digitally filtering said sample signals in order to produce said respective first and second digital signals,

step (b) further including the step of adjusting the gains of said modulators in response to variations in said first and second analog signals,

step (b) further including the steps of using first and second light emitting diodes for producing said respective first and second wavelengths, using a drive circuit for selectively activating said diodes, and determining the occurrence of a short circuit connected to said diodes and responsive thereto for deactivating said diodes.