Hydrolytically stable resins for use in anion-exchange chromatography
First Claim
1. An anion-exchange chromatographic composition comprising:
- (a) synthetic resin support particles; and
(b) quaternary ammonium salt anion-exchange sites attached to said synthetic resin support particles, wherein said anion-exchange sites are attached to said support particles through a chemical structure which comprises (i) a chemically reactive group which is selected from the group consisting of an ester, ketone or amide group and (ii) a linker separating said chemically reactive group from the nitrogen atom of said anion-exchange site, wherein said linker is at least four atoms in length.
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Abstract
In accordance with the present invention, an improved anion-exchange chromatographic composition has been formed which comprises synthetic resin support particles and anion exchange compounds attached thereto, wherein the anion-exchange compounds comprise an internal reactive group, which may be an ester, ketone or amide group, and a terminal quaternary ammonium salt which functions as an anion-exchange site. The compositions of the present invention exhibit improved hydrolytic stability as compared to other known anion-exchange chromatographic compositions due to the presence of linkers which increase the number of atoms separating the internal reactive group from the nitrogen atom of the terminal ammonium anion-exchange site. Formed articles and methods employing the anion-exchange chromatographic composition are also provided.
25 Citations
32 Claims
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1. An anion-exchange chromatographic composition comprising:
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(a) synthetic resin support particles; and (b) quaternary ammonium salt anion-exchange sites attached to said synthetic resin support particles, wherein said anion-exchange sites are attached to said support particles through a chemical structure which comprises (i) a chemically reactive group which is selected from the group consisting of an ester, ketone or amide group and (ii) a linker separating said chemically reactive group from the nitrogen atom of said anion-exchange site, wherein said linker is at least four atoms in length. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32)
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Specification