Autoinfuser for resuscitation and method of infusion fluid injection

• US 5,938,636 A
• Filed: 06/20/1997
• Issued: 08/17/1999
• Est. Priority Date: 06/20/1997
• Status: Expired due to Term

• Current Assignee: Regents of the University of California (University of California), Board of Regents of the University of Texas System (University of Texas System)
• Original Assignee: Regents of the University of California (University of California), Board of Regents of the University of Texas System (University of Texas System)
• Inventors: Castaldo, Domenico, Henderson, Jerald M., Feenstra, Wendy R., Kramer, George C.
• Primary Examiner(s): MCDERMOTT, CORRINE MARIE
• Application Number:
  US08/880,005
• Time in Patent Office: 788 Days
• Field of Search: 604/65-67, 604/131, 604/140, 604/141
• US Class Current: 604/66
• CPC Class Codes: A61M 2230/04 Heartbeat characteristics, e.g. ECG, blood pressure modulation
• CPC Class Codes: A61M 2230/30 Blood pressure A61M2230/04 takes precedence
• CPC Class Codes: A61M 5/1483 using flexible bags externally pressurised by fluid pressure
• CPC Class Codes: A61M 5/1723 using feedback of body parameters, e.g. blood-sugar, pressure measurement of body parameters A61B5/00

Abstract

The present invention relates to an apparatus for injecting infusion fluids into a patient at a controlled infusion rate. This apparatus is referred to as a "controlled autoinfuser". A preferred embodiment of the invention comprises a computer capable of using pressure volume and relationships to generate a control signal that will control the injection of infusion fluids into a patient. The present invention further comprises a method of controlling the injection of infusion fluids into a patient through the use of a microprocessor controlled autoinfuser as well as a method of injecting a preselected volume of infusion fluid into a patient within a preselected infusion time.

Claims

1. An apparatus for injecting infusion fluids into a patient at a controlled infusion rate, comprising:

a. a pressurized infuser comprising a pressure container having a known initial volume, V_i, and a known initial pressure, P_i, a flexible infusion fluid bag having volume V_f, contained within said pressure container, an infusion fluid outlet port in fluid communication with said bag, a pressure sensor located within said container and capable of measuring container pressure and emitting a process signal indicative of measured container pressure, P_m ;

b. a flow control valve comprising a valve inlet and a valve outlet, said inlet being in fluid communication with said infusion fluid outlet port;

c. a valve controller coupled to said valve to control the position of said valve in response to a control signal, said controller comprising a control signal receiver, and

d. a programmable computer coupled to receive at least one signal from said pressure sensor indicative of container pressure, said computer having a memory comprising stored values for V_i P_i, infusion time period, K6, a target infusion rate, TIR, and said computer further comprising algorithms derived from ideal gas laws, said computer being capable of generating a control signal based upon said pressure sensor signal and said stored values, said computer further being capable of sending a control signal based upon said control instruction to said control signal receiver.

2. The apparatus of claim 1, wherein said flow control valve is a solenoid valve.

3. The apparatus of claim 1, wherein said pressure container comprises a gaseous driving fluid.

4. The apparatus of claim 1, further comprising a data input terminal electrically coupled to said memory capable of receiving data from an external source and transmitting inputted data to said memory.

5. The apparatus of claim 1, further comprising a vascular access device in fluid communication with said valve outlet.

6. The apparatus of claim 5, wherein said access device is an intraosseous device.

7. The apparatus of claim 1, wherein said pressure container is rigid.

8. The apparatus of claim 1 further comprising:

a. a container of pressurized driving fluid having an injection outlet;

b. a driving fluid valve having an inlet coupled to said injection outlet and a discharge section in fluid communication with said pressure container.

9. An apparatus for injecting infusion fluids into a patient at a controlled infusion rate, comprising:

a. a pressurized infuser comprising a pressure container having a known initial volume, V_i, and a known initial pressure, P_i, a flexible infusion fluid bag having volume V_f, contained within said pressure container, an infusion fluid outlet port in fluid communication with said bag, a pressure sensor located within said container and capable of measuring container pressure and emitting a process signal indicative of measured container pressure, P_m ;

b. a flow control valve comprising a valve inlet and a valve outlet, said inlet being in fluid communication with said outlet infusion fluid port;

c. a valve controller coupled to said valve to control the position of said valve in response to a control signal, said controller comprising a control signal receiver;

d. a physiological sensor attachable to a patient and capable of measuring a physiological parameter, and transmitting a signal indicative of said measured physiological parameter MPP; and

e. a programmable computer electrically coupled to receive input signals from said pressure sensor and said physiological sensor, indicative of container pressure and said measured physiological parameter, respectively, said computer further comprising a memory comprising stored values for V_i, P_i, infusion time period K6, and a target physiological parameter value, TPP, and further comprising algorithms derived from combined gas laws, said algorithms being capable of comparing said target physiological parameter to said measured physiological parameter and further capable of generating at least one control instruction based upon said parameter comparison and further based upon said pressure sensor signal and values stored in memory, said computer further being capable of sending a control signal, based upon said control instruction, to said control signal receiver.

10. The apparatus of claim 9, wherein said measured physiological parameter is blood pressure.

11. The apparatus of claim 9 where said measured physiological parameter is indicative of blood or tissue oxygenation or of blood or tissue lactate.

12. The apparatus of claim 9, further comprising a vascular access device coupled to said valve outlet.

13. The apparatus of claim 9 wherein said pressure container is rigid.