Inhaled insulin dosage control delivery enhanced by controlling total inhaled volume
DCFirst Claim
1. A method of administering a formulation to a human patient by inhalation, comprising:
- (a) exhaling a determined volume of air;
(b) aerosolizing a formulation comprised of a pharmaceutically active compound;
(c) inhaling the aerosolized formulation with a determined volume of air; and
(d) repeating (a), (b) and (c) a plurality of times wherein the determined volume of air exhaled in (a) is substantially the same for each step (a) and the determined volume of air in (c) is substantially the same for each step (c).
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Accused Products
Abstract
Dosages of inhaled insulin are controlled within a narrow range by controlling the total volume of air inhaled by a patient. By repeatedly delivering aerosolized insulin with the same total inhaled volume of air, the amount of insulin delivered to the patient each time is consistent. A device for delivering insulin by inhalation is disclosed which device comprises a means for measuring inhaled volume and for halting inhalation at a pre-determined point. The device also comprises an adjustable means for applying various amounts of force to a container of formulation to expel different amounts of drug from the container based on the force applied.
112 Citations
26 Claims
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1. A method of administering a formulation to a human patient by inhalation, comprising:
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(a) exhaling a determined volume of air; (b) aerosolizing a formulation comprised of a pharmaceutically active compound; (c) inhaling the aerosolized formulation with a determined volume of air; and (d) repeating (a), (b) and (c) a plurality of times wherein the determined volume of air exhaled in (a) is substantially the same for each step (a) and the determined volume of air in (c) is substantially the same for each step (c). - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15)
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16. A drug delivery device, comprising:
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a channel comprising a first opening into which air can be inhaled, a second opening from which air can be withdrawn and a third opening through which aerosolized particles enter the channel; a container having a drug formulation therein; and a means for applying physical force to the formulation wherein the force results in aerosolization of formulation; a means for determining the volume of inhaled aerosol and inhaled air, a disposable porous membrane through which the formulation is forced, the membrane having pores with a diameter of about 0.5 to 3 microns; a means for moving disposable membranes into a drug release position for use in aerosolization and out of the drug release position after use; and an adjustable means for applying different degrees of force to the formulation wherein the different degrees of force correspond to set amounts of formulation which will be expelled from the container by the force. - View Dependent Claims (17, 18, 19, 20, 21, 22, 23, 24, 25, 26)
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Specification