Method for controlled contraction of collagen tissue via non-continuous energy delivery

• US 5,948,011 A
• Filed: 10/28/1997
• Issued: 09/07/1999
• Est. Priority Date: 05/05/1995
• Status: Expired due to Term

• Current Assignee: Thermage Incorporated (Bausch Health Cos., Inc.)
• Original Assignee: Thermage Incorporated (Bausch Health Cos., Inc.)
• Inventors: Knowlton, Edward W.
• Primary Examiner(s): Dvorak, Linda C. M.
• Assistant Examiner(s): YARNELL, BRYAN KEITH
• Application Number:
  US08/958,305
• Time in Patent Office: 679 Days
• Field of Search: 607/96, 607/108, 607/98-104, 606/2, 606/9, 606/33, 606/41, 128/898
• US Class Current: 607/101
• CPC Class Codes: A61B 18/12 by passing a current through the tissue to be heated, e.g. high-frequency current
• CPC Class Codes: A61B 18/1206 Generators therefor
• CPC Class Codes: A61B 18/14 Probes or electrodes therefor
• CPC Class Codes: A61B 2018/00488 Esophagus
• CPC Class Codes: A61B 2018/0066 without feedback, i.e. open loop control
• CPC Class Codes: A61M 15/0028 using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
• CPC Class Codes: A61M 15/0036 hollow piercing means
• CPC Class Codes: A61M 15/0041 with movable piercing or cutting means
• CPC Class Codes: A61M 2202/064 Powder
• CPC Class Codes: A61M 2205/073 Syringe, piston type
• CPC Class Codes: A61N 5/04 Radiators for near-field treatment

Abstract

A method for applying radiant energy through the skin to underlying collagen tissue without substantially modifying melanocytes and other epithelial cells in the epidermis by delivering non-continuous energy. A porous membrane is adapted to receive an electrolytic solution and become inflated to substantially conform a contacting exterior surface of the membrane to a skin layer. The membrane includes a cooling lumen for receiving cooling fluid. One or more thermal electrodes positioned in the membrane and transfers thermal energy to the electrolytic solution. The electrolytic solution and cooling fluid creates a reverse thermal gradient from the skin surface to the underlying collagen tissue. A thermal power source is coupled to the thermal electrodes, and a source of electrolytic solution is coupled to the membrane.

Claims

1. A method of tightening a skin surface overlying a collagen containing tissue site, comprising:

providing an RF energy source;

reducing a temperature of at least a portion of the skin surface, wherein the temperature of the skin surface is less than the temperature of the collagen containing tissue site when the temperature of the skin surface is reduced;

non-continuously delivering energy through the skin surface and an epidermis to the collagen containing tissue site;

contracting at least a portion of collagen in the collagen containing tissue site with a minimal cellular destruction in the epidermis; and

tightening the skin surface.

2. The method of claim 1, further comprising:

an RF electrode coupled to the RF energy source, the RF electrode including an RF energy delivery surface positionable on the skin surface.

3. The method of claim 2, further comprising:

providing a source of electrolytic solution coupled to RF electrode.

4. The method of claim 1, wherein the collagen containing tissue site is partially denatured by cleaving heat labile cross-links of collagen molecules.

5. The method of claim 1, further comprising:

non-continuously delivering a cooling medium to the skin surface.

6. The method of claim 1, wherein the collagen containing tissue site is in a subdermal layer.

7. The method of claim 1, wherein the collagen containing tissue site is in a deep dermal layer.

8. The method of claim 1, wherein the collagen containing tissue site is in a subcutaneous layer.

9. The method of claim 1, wherein the collagen containing tissue site is in facial and muscle tissue.

10. The method of claim 1, wherein the temperature of the collagen containing tissue site does not exceed 80 degrees C.

11. The method of claim 1, wherein the temperature of the collagen containing tissue site does not exceed 75 degrees C.

12. The method of claim 1, wherein the temperature of the collagen containing tissue site does not exceed 70 degrees C.

13. A method of tightening a skin surface overlying a collagen containing tissue site, comprising:

providing an RF energy source;

non-continuously reducing a temperature of at least a portion of the skin surface, wherein the temperature of the skin surface is less than the temperature of the collagen containing tissue site when the temperature of the skin surface is reduced;

delivering energy through the skin surface and an epidermis to the collagen containing tissue site;

contracting at least a portion of collagen in the collagen containing tissue site with a minimal cellular destruction in the epidermis; and

tightening the skin surface.

14. The method of claim 13, further comprising:

non-continuously delivery energy through the skin surface and the epidermis to the collagen containing tissue site.