Carbapenem antibiotic

• US 5,952,323 A
• Filed: 04/22/1998
• Issued: 09/14/1999
• Est. Priority Date: 05/28/1996
• Status: Expired due to Term

• Current Assignee: Merck Sharp & Dohme Corporation (Merck & Co., Inc.)
• Original Assignee: Merck & Co., Inc.
• Inventors: Zimmerman, Jeffrey A., Bergquist, Paul A., DuBost, David C., DiMichele, Lisa M., Williams, John M., Kaufman, Michael J., Sidler, Daniel R., Hunke, William A.
• Primary Examiner(s): FAY, ZOHREH A
• Application Number:
  US09/064,426
• Time in Patent Office: 510 Days
• Field of Search: 514/210, 540/200, 540/350, 548/413, 548/537
• US Class Current: 514/210.13
• CPC Class Codes: C07D 477/20 Sulfur atoms

Abstract

A pharmaceutical composition is disclosed which contains a compound of formula I: ##STR1## or a pharmaceutically acceptable salt, prodrug or hydrate thereof, in the stabilized form and/or in combination with a carbon dioxide source.

Claims

1. A compound represented by the formula II:

##STR8## or a pharmaceutically acceptable salt, prodrug or hydrate thereof.

3. A compound in accordance with claim 1 wherein the pharmaceutically acceptable salt is selected from the group consisting of:

##STR10## wherein X⁺ represents a pharmaceutically acceptable cationic group.

2. A pharmaceutical composition which is comprised of a compound represented by formula II:

##STR9## or a pharmaceutically acceptable salt, prodrug or hydrate thereof, in combination with a pharmaceutically acceptable carrier.

4. A method of stabilizing a carbapenem of the formula I:

##STR11## or a pharmaceutically acceptable salt, prodrug or hydrate thereof, comprising adding to the compound a sufficient amount of a carbon dioxide source to form a compound of formula II;

##STR12## or a pharmaceutically acceptable salt, prodrug or hydrate thereof.

5. A method in accordance with claim 4 wherein the carbon dioxide source is selected from carbon dioxide, sodium carbonate and sodium bicarbonate.

6. A method in accordance with claim 5 wherein the carbon dioxide source is selected from sodium carbonate and sodium bicarbonate.