Submicron emulsions as vaccine adjuvants

  • US 5,961,970 A
  • Filed: 04/29/1996
  • Issued: 10/05/1999
  • Est. Priority Date: 10/29/1993
  • Status: Expired due to Fees
First Claim
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1. A vaccine adjuvant composition of an oil-in-water submicron emulsion consisting essentially of about 0.5 to 50% of a first component of an oil, about 0.1 to 10% of a second component of an emulsifier, wherein the emulsifier is a phospholipid compound or a mixture of phospholipids selected from the group consisting of phosphatidylcholine, phosphatidylethanolamine, phosphatidylserine, phosphatidylinositol, phosphatidylglycerol, phosphatidic acid, sphingomyelin and cardiolipin, about 0.05 to 5% of a non-ionic surfactant, about 0.00001, to 1% of an immunogen, and an aqueous continuous phase, said submicron emulsion having a mean droplet size in the range of between about 0.03 and 0.5 μ

  • m, which composition is substantially free of added amounts of muramyl peptides or their lipophilic derivatives.

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