Inhibitors of prenyl transferases
First Claim
Patent Images
1. A peptidomimetic of the formula:
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space="preserve" listing-type="equation">Cβ
XwhereinC is a 3-mercapto-2-amino-propylamino group;
X is an amino acid; and
β
is a residue of an optionally substituted aminobenzoic acid or an optionally substituted aminonaphthoic acid.
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Abstract
Compounds which inhibit prenyl transferases, particularly farnysyltransferase and geranylgeranyl transferase I, processes for preparing the compounds, pharmaceutical compositions containing the compounds, and methods of use.
24 Citations
26 Claims
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1. A peptidomimetic of the formula:
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space="preserve" listing-type="equation">Cβ
Xwherein C is a 3-mercapto-2-amino-propylamino group; X is an amino acid; and β
is a residue of an optionally substituted aminobenzoic acid or an optionally substituted aminonaphthoic acid. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 20, 21, 22, 23, 24, 26)
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12. A compound of the formula:
- wherein R represents H or CH3 ;
or OR, taken together with the carbonyl group to which it is bonded, represents a lipophilic esterase-sensitive moiety,and R1 represents H or a substituted or unsubstituted phenyl group. - View Dependent Claims (13, 14, 15, 25)
- wherein R represents H or CH3 ;
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16. A compound of the formula ##STR15## wherein R represents H or CH3 ;
- or OR, taken together with the carbonyl group to which it is bonded, represents a lipophilic esterase-sensitive moiety,
and R1 represents H or a substituted or unsubstituted phenyl group. - View Dependent Claims (17)
- or OR, taken together with the carbonyl group to which it is bonded, represents a lipophilic esterase-sensitive moiety,
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18. A compound of the formula ##STR16## wherein R represents H or CH3 ;
- or OR, taken together with the carbonyl group to which it is bonded, represents a lipophilic esterase-sensitive moiety.
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19. A compound of the formula ##STR17## wherein R represents H or CH3 ;
- or OR, taken together with the carbonyl group to which it is bonded, represents a lipophilic esterase-sensitive moiety,
and R1 represents H, CH3 or OCH3.
- or OR, taken together with the carbonyl group to which it is bonded, represents a lipophilic esterase-sensitive moiety,
Specification