Apparatus and method for monitoring respiratory function in heart failure patients to determine efficacy of therapy

• US 5,974,340 A
• Filed: 04/29/1997
• Issued: 10/26/1999
• Est. Priority Date: 04/29/1997
• Status: Expired due to Fees

• Current Assignee: Cardiac Pacemakers Incorporated (Boston Scientific Corporation)
• Original Assignee: Cardiac Pacemakers Incorporated (Boston Scientific Corporation)
• Inventors: Kadhiresan, V. A.
• Primary Examiner(s): Kamm, William E.
• Application Number:
  US08/840,425
• Time in Patent Office: 910 Days
• Field of Search: 607/18, 607/19, 607/20
• US Class Current: 607/18
• CPC Class Codes: A61N 1/3627 for treating a mechanical deficiency of the heart, e.g. congestive heart failure or cardiomyopathy
• CPC Class Codes: A61N 1/36521 the parameter being derived from measurement of an electrical impedance
• CPC Class Codes: A61N 1/36542 controlled by body motion, e.g. acceleration

Abstract

The respiratory function of a patient is measured for diagnostic purposes using a cardiac rhythm management device. Monitoring of the respiratory activity is initiated after a microprocessor in the cardiac rhythm management device determines that the patient has been at rest for a predetermined length of time. A respiration related signal is derived from either an accelerometer signal or from an impedance sensor, depending upon which produces a signal has the higher signal-to-noise ratio. The signal from either the accelerometer or impedance measuring mechanism is low-pass filtered to obtain a respiratory signal component. The respiratory signal component is digitized and sent to the microprocessor for analysis. The microprocessor can be programmed in either of two modes of analysis. In the first mode, the peak-to-peak values of the respiratory signal component over a number of fixed time interval is summed, obtaining the minute volume. In the second method, the entire waveform history during the fixed time interval is stored in the microprocessor. The stored information is then telemetered out to the physician when interrogated. The physician may then review the information and then determines the efficacy of a treatment regimen administered to the patient.

Claims

1. A cardiac rhythm management device having means for sensing events of a patient'"'"'s cardiac activity and means for applying stimulating pulses to the patient'"'"'s heart at timed intervals, the device including an impedance measurement means for producing a signal representative of intracardiac volume and an accelerometer for producing a signal representative of patient activity and mechanical movement of cardiac tissue of said patient, said cardiac rhythm management device comprising:

a) first signal processing means coupled to said impedance measurement means for producing a first signal component representative of minute volume of said patient over a predetermined number of respiratory cycles;

b) second signal processing means coupled to said accelerometer for producing a second signal component representative of said patient'"'"'s mechanical movement events due to respiration; and

c) a controller having a programmed microprocessor coupled to said first and second signal processing means and having timing means, means for receiving said first and second signal components, means for selectively analyzing the first and second signal components over said predetermined number of respiratory cycles during a predetermined time interval defined by said timing means, and means for storing a selected one of the first and second signal components for subsequent retrieval and analysis.

2. A cardiac rhythm management device of claim 1 and further including telemetering means for transmitting said stored first and second signal components and an external device for receiving the first and second signal components.

3. A cardiac rhythm management device of claim 1 wherein said means for selectively analyzing further includes means for evaluating signal-to-noise ratio of said first and second signal components and means for selecting a one of the first and second signal components having the greater signal-to-noise ratio as the signal component stored by the storing means.

4. A cardiac rhythm management device of claim 3 wherein said controller further includes means for determining whether said patient is at rest and means responsive to the at rest determining means for inhibiting the signal-to-noise ratio evaluating means until an at rest state condition is satisfied.

5. A cardiac rhythm management device for a patient'"'"'s heart, said cardiac rhythm management system comprising:

a) means for sensing cardiac depolarization events and producing a first signal representative thereof;

(b) means for applying cardiac stimulating signals to the heart;

(c) impedance measuring means for generating a second signal representative of intracardiac impedance, including components correlating with events of respiration of the patient;

(d) an accelerometer for generating a third signal including components correlating with mechanical events of the patient'"'"'s respiration; and

(e) a controller having a microprocessor coupled to said sensing means, said accelerometer and said impedance measurement means, said controller having means for determining from the third signal when said patient is at rest, means for initiating an analysis of said second and third signals only when the patient is at rest, analyzing means for selectively analyzing one of said second and third signals over a predetermined time interval while said patient is at rest, means for storing said analyzed signal, and means responsive to said first signal and at least one of the second and third signals for controlling said means for applying cardiac signals to the heart.

6. A cardiac rhythm management device of claim 5 and further including telemetering means for transmitting said stored analyzed signal, and an external device for receiving the analyzed signals.

7. A cardiac rhythm management device of claim 5 wherein said analyzing means for selectively analyzing further includes means for evaluating signal-to-noise ratio of said first and second signals and selecting for analysis the one of said first and second signals with a higher signal-to-noise ratio.

8. A method for monitoring respiratory function of a patient comprising the steps of:

a) implanting a cardiac rhythm management device within a patient, the cardiac rhythm management device having a controller with a microprocessor, a memory, a means for measuring intracardiac impedance and an accelerometer for sensing mechanical events relating to respiratory activity of the patient, a means for sensing cardiac depolarization events and a means for applying cardiac stimulating pulses to the patient'"'"'s heart;

b) receiving a first signal from the accelerometer;

c) receiving a second signal from the means for measuring intracardiac impedance;

d) determining from the first signal if said patient is a rest;

e) evaluating said first and second signals to determine a signal-to-noise ratio for said first and second signals when said patient is at rest;

f) selecting the one of the first and second signals having the higher signal-to-noise ratio;

g) setting a predetermined time interval;

h) filtering said selected signal to obtain a portion of the selected signal corresponding to respiratory activity of said patient;

i) measuring said selected signal for said predetermined time interval;

j) storing said measured selected signal in said memory of said controller; and

k) repeating steps b-j until patient is no longer at rest.

9. A method of claim 8 and further comprising the steps of:

telemetering said stored signal.

10. A method of claim 8 and further comprising the step of storing the waveform of the selected signal of each time interval while said patient is at rest for subsequent retrieval and analysis.

11. A method for monitoring respiratory function of a patient comprising the steps of:

a) implanting in such patient a cardiac rhythm management device having means for sensing cardiac depolarization events, means for applying electrical stimulation signals to the patient, an accelerometer for sensing mechanical respiration events, an impedance measuring means for sensing intracardiac impedance and a controller with a programmed microprocessor having a memory, the microprocessor receiving a first signal corresponding to said cardiac depolarization events, a second signal corresponding to mechanical respiration events and a third signal corresponding to intracardiac impedance;

b) determining from the second signal whether the patient is at rest;

c) evaluating said second and third signals when said patient is at rest;

to determine a signal-to-noise ratio for said second and third signals;

d) selecting the one of the second and third signals with the greater signal-to-noise ratio;

e) filtering said selected signal to obtain a component of said selected signal corresponding to respiratory activity of said patient;

f) measuring peak-to-peak values of said selected signal over a predetermined time interval;

g) summing measured peak-to-peak values;

h) storing said summed peak-to-peak values in said memory of said microprocessor for subsequent retrieval and analysis;

i) repeating steps b-h until patient is no longer at rest; and

j) updating a counter for each iteration of steps b-h.

12. A method of claim 11 and further comprising the step of telemetering the stored signals.