Aqueous-based pharmaceutical composition

  • US 5,976,573 A
  • Filed: 07/03/1996
  • Issued: 11/02/1999
  • Est. Priority Date: 07/03/1996
  • Status: Expired due to Term
First Claim
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1. An aqueous pharmaceutical composition which is capable of being sprayed into the nasal cavity of an individual and which comprises:

  • (A) a pharmaceutically effective amount of solid particles of triamcinolone acetonide which is effective in treating an abnormal bodily condition by virtue of its being present on the mucosal surfaces of the nasal cavity; and

    (B) a suspending agent in an amount effective to maintain said particles dispersed uniformly in the composition and to impart to the composition the following thixotropic properties;

    (i) the viscosity of the composition in unsheared form is relatively high, with the composition being a gel having said particles suspended therein;

    (ii) as the composition is subjected to shear (shaken) in preparation for spraying, the viscosity of the composition becomes relatively low and such that the composition in the form of a mist flows readily into the nasal passages for deposit on the mucosal surfaces of the nasal cavity; and

    (iii) in deposited form on the mucosal surfaces, the viscosity of the composition is relatively high and such that it resists being cleared from the mucosal surfaces by the inherent mucocillary forces which are present in the nasal cavity.

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