System and method for preventing, diagnosing, and treating genetic and pathogen-caused disease

• US 5,985,559 A
• Filed: 05/03/1997
• Issued: 11/16/1999
• Est. Priority Date: 04/30/1997
• Status: Expired due to Term

• Current Assignee: Health Hero Network Incorporated (Robert Bosch GmbH)
• Original Assignee: Health Hero Network Incorporated (Robert Bosch GmbH)
• Inventors: Brown, Stephen J.
• Primary Examiner(s): Degen, Nancy
• Application Number:
  US08/850,840
• Time in Patent Office: 927 Days
• Field of Search: 435/6, 435/172.1, 435/172.3, 435/4, 435/283.1, 435/285.1, 435/287.1, 435/288.7, 435/287.2, 436/63
• US Class Current: 435/6.11
• CPC Class Codes: A61B 2560/0443 Modular apparatus
• CPC Class Codes: A61B 5/0002 Remote monitoring of patients using telemetry, e.g. transmission of vital signals via a communication network A61B5/07 takes precedence; transmission systems for measured values G08C; transmission H04B; transmission of digital information H04L; wireless communication networks H04W
• CPC Class Codes: A61B 5/0205 Simultaneously evaluating both cardiovascular conditions and different types of body conditions, e.g. heart and respiratory condition
• CPC Class Codes: A61B 5/087 Measuring breath flow
• CPC Class Codes: A61B 5/14532 for measuring glucose, e.g. by tissue impedance measurement
• CPC Class Codes: A61B 5/416 the spleen
• CPC Class Codes: A61B 5/4839 combined with drug delivery
• CPC Class Codes: A61B 5/6896 Toys
• CPC Class Codes: G16H 10/20 for electronic clinical trials or questionnaires
• CPC Class Codes: G16H 10/60 for patient-specific data, e.g. for electronic patient records
• CPC Class Codes: G16H 40/40 for the management of medical equipment or devices, e.g. scheduling maintenance or upgrades
• CPC Class Codes: G16H 40/67 for remote operation

Abstract

Genetic testing allows an individual to determine whether or not he or she has a predisposition to a certain disease. The degree of expressivity of a certain disease will be determined in part by an individual'"'"'s environment and lifestyle. The present invention interprets a patient'"'"'s gene sequence and his or her environment and lifestyle to come up with a personalized prognosis. This procedure can be repeated many times over the course of a disease state to monitor a patient'"'"'s condition. In addition, disease-causing pathogens can also have their genes sequenced. Using these sequences in combination with information about a patient'"'"'s environment and lifestyle, it is possible to come up with a personalized treatment plan, ideally to eliminate the pathogen. It is also possible to use the procedure described above to monitor the course of the disease-state produced by a pathogen. Finally, a genotype-to-phenotype map or database can be constructed for developing better treatments and for research purposes.

Claims

1. A system for developing a personalized treatment, the system comprising:

a) a means for sequencing a gene and for providing at least one patient-specific gene sequence;

b) a database of known gene sequences and associated scripts assigned to said known gene sequences; and

c) a health monitor for interpreting said at least one patient-specific gene sequence, for receiving said associated scripts from said database, for presenting said associated scripts to a patient and for determining a degree of expressivity of a phenotype associated with a genotype based on a response of the patient to said associated scripts.

2. The system of claim 1, wherein said associated scripts comprise questions about the patient'"'"'s environment and lifestyle.

3. The system of claim 2, wherein said health monitor presents said associated scripts to the patient more than once.

4. The system of claim 1, wherein said means for sequencing a gene allows analysis of said gene.

5. The system of claim 1, wherein said database is remote from said health monitor and connected to said health monitor by means of a network.

6. The system of claim 1, wherein said response of the patient to said associated scripts is used to construct a genotype-to-phenotype map.

7. The system of claim 1, wherein said response of the patient to said associated scripts is used to construct a genotype phenotype knowledge base.

8. The system of claim 1, wherein said at least one patient-specific gene sequence is associated with a disease condition.