Compositions comprising hyaluronic acid and drugs

  • US 5,985,850 A
  • Filed: 06/05/1995
  • Issued: 11/16/1999
  • Est. Priority Date: 09/21/1989
  • Status: Expired due to Term
First Claim
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1. A dosage amount of a pharmaceutical composition containing a suitable pharmaceutically acceptable excipient comprising:

  • (1) a therapeutically effective amount of an agent to treat a disease or condition involving underperfused tissue and pathological tissue in humans;

    and (2) a form of hyaluronic acid selected from the group consisting of hyaluronic acid and pharmaceutically acceptable salts thereof and combinations thereofcharacterized in that said dosage amount of said composition(a) is in a dosage form which is suitable for administration in humans;

    and (b) is in a form in which (i) component (1) is in an effective dosage amount to treat said disease or condition involving underperfused tissue and pathological tissue by penetration at the site to be treated; and

    (ii) component (2) is available to transport component (1) from the point of administration to the site to be treated, and which component (2) is in an effective non-toxic amount to facilitate the transport of component (1) upon administration from the site of administration to the site in need of treatment, through the tissue, at the site to be treated and through cell membranes into individual cells to be treated, wherein said amount of component (2) is sufficient to provide a dosage of 10 mg to 3000 mg of component (2) and wherein the molecular weight of component (2) is less than 750,000 daltons and greater than 150,000 daltons.

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