Substantive topical composition

• US 5,989,529 A
• Filed: 11/20/1998
• Issued: 11/23/1999
• Est. Priority Date: 11/20/1998
• Status: Expired due to Term

• Current Assignee: MSD CONSUMER PRODUCTS Incorporated (Merck & Co., Inc.)
• Original Assignee: Schering-Plough Healthcare Products Incorporated (Merck & Co., Inc.)
• Inventors: Kaplan, Carl
• Primary Examiner(s): Dodson, Shelley A.
• Application Number:
  US09/208,091
• Time in Patent Office: 368 Days
• Field of Search: 424/59, 424/60, 424/400, 424/401, 424/78.02, 424/78.08, 424/78.17, 514/937, 514/938
• US Class Current: 424/59
• CPC Class Codes: A61K 8/046 Aerosols; Foams
• CPC Class Codes: A61K 8/35 Ketones, e.g. benzophenone
• CPC Class Codes: A61K 8/37 Esters of carboxylic acids
• CPC Class Codes: A61K 8/445 aromatic, i.e. the carboxylic acid directly linked to the aromatic ring
• CPC Class Codes: A61K 8/90 Block copolymers A61K8/89 takes precedence
• CPC Class Codes: A61Q 17/04 Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations

Abstract

A dermatologically compatible substantive oil-in-water sunscreen composition is disclosed comprising a block polymer substantive agent and a sunscreening agent. The composition is adaptable for dispensing by a spray means.

Claims

1. A substantive oil-in-water sunscreen composition comprising:

A. a substantive agent comprising a block polymer containing poly(hydroxylated ester) blocks and polyethylene glycol blocks;

B. one or more oil soluble sunscreening UV-B active agents or a mixture of one or more UV-B actives and one or more UV-A actives;

C. at least one emulsifier; and

D. water.

2. The composition of claim 1 wherein the polyethylene glycol blocks of said substantive agent have from about 4 to about 50 mol of ethylene oxide.

3. The composition of claim 2 wherein the polyethylene glycol blocks of said substantive agent have from about 20 to about 40 mol of ethylene oxide.

4. The composition of claim 3 wherein the polyhydroxylated ester portion of said substantive agent is selected from the class consisting of oleates, palmitates, stearates and mixtures thereof.

5. The composition of claim 4 wherein the polyhydroxylated ester portion of said substantive agent has a C₁₂ -C₂₀ chain length.

6. The composition of claim 5 wherein the substantive agent comprises PEG 30 dipolyhydroxystearate.

7. The composition of claim 6 wherein the PEG 30 dipolyhydroxystearate is present at a concentration of about 0.01 to about 10 percent by weight of the total composition.

8. The composition of claim 7 wherein the PEG 30 dipolyhydroxystearate is present at a concentration of about 3 to about 8 percent by weight of the total composition.

9. The composition of claim 8 wherein the oil soluble sunscreening active agent comprises a sunscreen selected from the class consisting of octocrylene, octylsalicylate, homosalate, ethylhexyl-p-methoxy cinnamate, oxybenzone, avobenzone and menthyl anthranilate.

10. The composition of claim 9 wherein the sunscreen comprises from about 1 percent to about 35 percent by weight of the total composition.

11. The composition of claim 10 wherein the sunscreen comprises from about 3 to about 27 percent by weight of the total composition.

12. The composition of claim 11 wherein the sunscreen comprises octocrylene.

13. The composition of claim 11 wherein the sunscreen comprises octylsalicylate.

14. The composition of claim 11 wherein the sunscreen comprises homosalate.

15. The composition of claim 11 wherein the sunscreen comprises ethyl-p-methoxycinnamate.

16. The composition of claim 11 wherein the sunscreen comprises oxybenzone.

17. The composition of claim 11 wherein the sunscreen comprises avobenzone.

18. The composition of claim 11 wherein the sunscreen comprises menthyl anthranilate.

19. A dermatologically compatible substantive sunscreening oil-in-water emulsion composition having a pH of about 6 to 10 comprising:

A. about 1 percent to about 35 percent by weight of a sunscreen selected from octocrylene, octyl salicylate, homosalate, ethylhexyl-p-methoxy cinnamate, oxybenzone, avobenzone and menthyl anthranilate;

B. about 3 percent to about 8 percent by weight of a substantive agent comprising a block polymer containing a poly(hydroxylated ester) block and a polyethelene glycol block;

C. about 0.05 to about 20 percent by weight of an emulsifier; and

D. about 45 to about 75 percent by weight water.

20. The composition of claim 19 wherein the polyethylene glycol block of said substantive agent comprises about 4 to about 50 mol ethylene oxide and wherein the poly(hydroxylated ester) block of said substantive agent comprises a C₁₂ -C₂₀ chain length.

21. The composition of claim 20 wherein said substantive agent comprises PEG 30 dipolyhydroxystearate.

22. The composition of claim 21 wherein the sunscreen comprises about 3 percent to about 27 percent of the total composition by weight.

23. The composition of claim 22 wherein the PEG 30 dipolyhydroxystearate comprises about 3 to about 6 percent by weight of the total composition.

24. A dermatologically compatible substantive sunscreening oil-in-water emulsion for dispensing via a spray means comprising:

A. about 1 percent to about 35 percent by weight of a sunscreen selected from octocrylene, octylsalicylate, homosalate, ethyl-p-methoxy cinnamate, oxybenzone, avobenzone and menthyl anthranilate; and

B. about 1 percent to about 7 percent of a PEG 30 dipolyhydroxystearate.

25. The sunscreening oil-in-water emulsion of claim 24 wherein the sunscreen comprises about 3 to about 27 percent by weight of the total composition.