Device and method for determining analyte levels

  • US 6,001,067 A
  • Filed: 03/04/1997
  • Issued: 12/14/1999
  • Est. Priority Date: 03/04/1997
  • Status: Expired due to Term
First Claim
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1. A device for measuring glucose in a biological fluid, comprising:

  • a) a housing comprising electronic circuit means and at least two electrodes operably connected to said electronic circuit means; and

    b) a sensor means operably connected to said electrodes of said housing, said sensor means comprising i) means for determining the amount of glucose in a biological sample, said glucose determining means operably associated with said electrodes and comprising a membrane impregnated with an oxidase, ii) a bioprotective membrane, said bioprotective membrane positioned more distal to said housing than said glucose determining means and substantially impermeable to macrophages, and iii) an angiogenic layer, said angiogenic layer positioned more distal to said housing than said bioprotective membrane.

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