Extended release formulations of erythromycin derivatives

  • US 6,010,718 A
  • Filed: 04/11/1997
  • Issued: 01/04/2000
  • Est. Priority Date: 04/11/1997
  • Status: Expired due to Term
First Claim
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1. A pharmaceutical composition for extended release of an erythromycin derivative in the gastrointestinal environment, comprising an erythromycin derivative and from about 5 to about 50% by weight of a pharmaceutically acceptable polymer, so that when ingested orally, the composition induces statistically significantly lower mean fluctuation index in the plasma than an immediate release composition of the erythromycin derivative while maintaining bioavailability substantially equivalent to that of the immediate release composition of the erythromycin derivative.

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