Fluorescence scope system for dermatologic diagnosis

• US 6,021,344 A
• Filed: 12/03/1997
• Issued: 02/01/2000
• Est. Priority Date: 12/04/1996
• Status: Expired due to Term

• Current Assignee: Biomax Technologies Pte., Ltd., Coyote Ventures Corporation, LED Medical Diagnostics Incorporated (Planet DDS Incorporated)
• Original Assignee: Derma Art Technologies, Inc.
• Inventors: Zeng, Haishan, MacAulay, Calum E., Lui, Harvey, McLean, David I., Palcic, Branko
• Primary Examiner(s): Kamm, William E.
• Assistant Examiner(s): SHAW, SHAWNA JEANNINE
• Application Number:
  US08/984,391
• Time in Patent Office: 790 Days
• Field of Search: 600/476, 600/473, 600/475, 600/477, 600/478, 600/310, 600/317, 351/163, 351/165
• US Class Current: 600/476
• CPC Class Codes: A61B 2090/502 Headgear, e.g. helmet, spectacles
• CPC Class Codes: A61B 5/0059 using light, e.g. diagnosis by transillumination, diascopy, fluorescence A61B5/0093, A61B5/1455, A61B5/02416 and A61B5/0261 take precedence
• CPC Class Codes: A61B 5/0071 by measuring fluorescence emission
• CPC Class Codes: A61B 5/444 Evaluating skin marks, e.g. mole, nevi, tumour, scar

Abstract

Apparatus for the diagnosis of a skin disease site by visual fluorescence inspection comprising an excitation light source for illuminating the disease site, a light guide for transmitting the excitation light directly to the disease site to generate fluorescence light and viewing goggles for processing the excitation light reflected and the fluorescence light emitted from the disease site to provide a fluorescence image of the disease site to a user. The fluorescence image is used to aid the medical assessment of skin conditions and the diagnosis of cutaneous diseases by supplementing the visual assessment of skin lesions made by the naked eye. The apparatus can be used in several modes of operation that permit the viewing of full color fluorescence images and enhanced two color images. The apparatus can also use image intensifying equipment to amplify fluorescence light so that even very weak fluorescing objects can be seen. A method for acquiring and viewing the fluorescence images is also disclosed.

Claims

1. A binocular viewing apparatus comprising a frame adapted to be worn on the head of a user, the frame comprising first and second light filters fixedly mounted on either side of the frame, the first filter positioned to transmit a first independent fluorescence image to a first eye of the user and the second filter positioned to transmit a second independent fluorescence image to a second eye of the user, wherein each filter blocks at least light having a wavelength of about 442 nm or less and each filter is a band pass filter that passes the fluorescence light in at least two different selected wavelength bands.

2. Apparatus as claimed in claim 1 in which the frame is an eyeglass frame.

3. Apparatus as claimed in claim 1 in which the frame is a goggle frame.

4. Apparatus as claimed in claim 1 in which the first and second light filters comprise two identical light filters.

5. Apparatus as claimed in claim 1 in which the at least one filter blocks light having a wavelength of less than about 475 nm.

6. Apparatus as claimed in claim 1 in which the at least two selected wavelength bands are green light and red light.

7. Apparatus as claimed in claim 6 in which the green light is from about 480 nm to about 560 nm and the red light is from about 620 nm to about 700 nm.

8. Apparatus as claimed in claim 1 in which the apparatus further comprises at least one image intensifier that intensifies the light passing through at least one of the first and second light filters.

9. Apparatus as claimed in claim 8 in which the apparatus further comprises at least two image intensifiers, one for each of the first and second light filters.

13. Apparatus as claimed in claim 1 in which the apparatus further comprises an excitation light source attached to the frame, the excitation light source able to induce fluorescence in human skin in front of the first and second light filters.

14. Apparatus as claimed in claim 13 in which the apparatus further comprises a light guide that transmits the excitation light from the excitation light source to the skin.

15. Apparatus as claimed in claim 14 in which the light guide comprises an optic fiber having a microlens on an end of the fiber located near the skin.

16. Apparatus as claimed in claim 15 in which the light guide comprises an optic fiber bundle.

17. Apparatus as claimed in claim 15 in which the light guide comprises a liquid light guide.

18. Apparatus as claimed in claim 13 in which the excitation light source comprises a laser light source.

19. Apparatus as claimed in claim 13 in which the excitation light source comprises an arc lamp selected from the group consisting of a Mercury arc lamp, a Xenon arc lamp, and a metal halide lamp.

20. Apparatus as claimed in claim 13 in which the excitation light source is selected from the group consisting of a LED panel and a fluorescent UV lamp for direct illumination of the skin.

21. Apparatus as claimed in claim 13 in which the apparatus further comprises at least one image intensifier that intensifies the light passing through at least one of the first and second light filters.

22. Apparatus as claimed in claim 21 in which the excitation light source comprises a pulsed light source and the at least one image intensifier acquires an image only when the pulsed light source is activated.

31. Apparatus as claimed in any one of claims 1, 2 or 23 in which the apparatus does not comprise an image intensifier.

10. Apparatus as claimed 9 in which the first and second light filters comprise first and second band pass filters, the first band pass filter passing fluorescence light at a first wavelength band to the first image intensifier and the second band pass filter passing fluorescence light at a second wavelength band to the second image intensifier.

11. Apparatus as claimed in claim 10 further comprising an adjuster that adjusts the color of the fluorescence image transmitted to each eye.

12. Apparatus as claimed in claim 11 in which the adjuster comprises color filters located between the image intensifiers and the eyes of the user.

23. Apparatus for diagnosis of skin disease sites by visual fluorescence inspection comprising:

an excitation light source for providing excitation light for illuminating the disease site;

means for transmitting the excitation light directly to the disease site to generate fluorescence light; and

means for processing the excitation light reflected and the fluorescence light emitted from the disease site to provide a fluorescence image of the disease site to a user, wherein the means for processing comprises first and second band pass filters, each filter blocking the excitation light and passing the fluorescence light in at least two different preselected wavelength bands, wherein each filter is arranged in either side of binocular frames to transmit an independent fluorescence image to each eye of the user.

24. Apparatus as claimed in claim 23 in which the binocular frames are eyeglass frames.

25. Apparatus as claimed in claim 23 in which the binocular frames are goggle frames.

26. Apparatus as claimed in claim 23 in which the two or more light filters comprise two identical light filters.

27. Apparatus as claimed in claim 23 in which the means for processing the light includes image intensifying means associated with the two or more light filters.

28. Apparatus as claimed in claim 27 further comprising an adjuster that adjusts the color of the fluorescence image transmitted to each eye.

29. Apparatus as claimed in claim 28 in which the adjuster comprises color filters located between the image intensifiers and the eyes of the user.

30. Apparatus as claimed in claim 23 in which the excitation light source comprises a pulsed light source and the image intensifying means acquires an image only when the pulsed light source is activated.

32. A method of evaluating a potential human skin disease site by visual inspection comprising the steps of:

illuminating the disease site with a excitation light under conditions suitable and for a time sufficient to generate fluorescence light in the skin disease site;

passing the fluorescence light through at least one band pass light filter that passes the fluorescence light in at least two different selected wavelength bands, the at least one filter mounted in a binocular frame that is adapted to be disposed on the head of a user, the at least one filter blocking at least light having a wavelength of about 442 nm or less, thereby blocking the excitation light reflected from the disease site and transmitting the fluorescence light emitted from the disease site to at least one eye of the user to provide a transmitted fluorescence image; and

viewing and evaluating the transmitted fluorescence image.

33. A method as claimed in claim 32 in which the at least two different wavelength bands are green light and red light.

34. A method as claimed in claim 33 in which the green light is from about 480 nm to about 560 nm and the red light is from about 620 nm to about 700 nm.

35. A method as claimed in claim 32 in which the method does not comprise passing the image that is transmitted to the eyes of the user through an image intensifier.