Implantable heart stimulator with a maximum stimulation rate that is adjusted dependent on ischemia detection

• US 6,021,350 A
• Filed: 03/26/1998
• Issued: 02/01/2000
• Est. Priority Date: 03/26/1997
• Status: Expired due to Term

• Current Assignee: Pacesetter AB
• Original Assignee: Pacesetter AB
• Inventors: Mathson, Goran
• Primary Examiner(s): Kamm, William E.
• Assistant Examiner(s): EVANISKO, GEORGE ROBERT
• Application Number:
  US09/048,490
• Time in Patent Office: 677 Days
• Field of Search: 607/9, 607/17, 607/24
• US Class Current: 607/17
• CPC Class Codes: A61N 1/36557 controlled by chemical substances in blood
• CPC Class Codes: A61N 1/368 comprising more than one electrode co-operating with different heart regions A61N1/3622, A61N1/3627 take precedence

Abstract

An implantable heart stimulator includes a unit for setting a maximum allowable stimulation rate and an ischemia detector. An analysis unit and control unit and connected to the ischemia detector and to the setting unit for controlling the setting unit so as to lower the maximum allowable stimulation rate in response to the detection of an ischemic state.

Claims

1. An implantable heart stimulator comprising:

a pulse generator which emits stimulation pulses at a stimulation rate;

setting means, connected to said pulse generator, for setting a maximum allowable stimulation rate;

an ischemia detector which detects a state of ischemia; and

means connected to said ischemia detector and to said setting means for controlling said setting means for lowering said maximum allowable stimulation rate upon a detection of a state of ischemia by said ischemia detector.

2. An implantable heart stimulator as claimed in claim 1 further comprising:

an activity sensor which senses a level of physical activity of a subject and which emits an electrical signal identifying said level of physical activity; and

said means for controlling comprising means for controlling said setting means for setting said maximum allowable stimulation rate, in an absence of a detection of a state of ischemia, to a maximum stimulation rate programmed for the sensed level of activity.

3. An implantable heart stimulator as claimed in claim 1 further comprising:

a metabolic demand sensor which senses metabolic senses metabolic demand of a subject and which emits an electrical signal indicative of an activity level of a subject dependent on the senses metabolic demand; and

said means for controlling comprising means for controlling said setting means for setting said maximum allowable stimulation rate, in an absence of a detection of a state of ischemia, to a maximum stimulation rate programmed for the sensed level of activity.

4. An implantable heart stimulator as claimed in claim 1 further comprising:

means for sensing atrial electrical activity in an atrium;

means for delivering said stimulation pulses to a ventricle at a ventricular stimulation rate;

said means for controlling comprising means for controlling said ventricular stimulation rate dependent on said atrial electrical activity and said ventricular stimulation rate having a maximum tracking rate associated therewith; and

said control means comprising means for setting said maximum allowable stimulation rate equal to said maximum tracking rate.

5. An implantable heart stimulator as claimed in claim 1 wherein said ischemia detector comprises means for recording recorded signals selected from the group consisting of IECGs and ECGs, and means for detecting a state of ischemia by analyzing said recorded signals.

6. An implantable heart stimulator as claimed in claim 5 wherein said recorded signals have a baseline and contain ST segments and T waveforms, and wherein said means for detecting comprises means for identifying a state of ischemia dependent on an elevation from said baseline of said ST segments and said T waveforms in said recorded signals.

7. An implantable heart stimulator as claimed in claim 5 wherein said recorded signals contain T waveforms, and wherein said means for detecting comprises means for identifying a state of ischemia dependent on said T waveforms in said recorded signals.

8. An implantable heart stimulator as claimed in claim 5 wherein said means for detecting comprises means for identifying a state of ischemia dependent on heart rate variability identified from said recorded signals.

9. An implantable heart stimulator as claimed in claim 1 further comprising:

an electrode lead connected to said pulse generator for delivering said stimulation pulses to a heart, said lead experiencing bendings due to cardiac activity of said heart; and

said ischemia detector comprising a lead bending sensor disposed at a distal end of said lead and means for identifying a state of ischemia dependent on a frequency and amplitude of bending of said lead.

10. An implantable heart stimulator as claimed in claim 1 wherein said ischemia detector comprises means for measuring an AC impedance in a ventricle.

11. An implantable heart stimulator as claimed in claim 1 wherein said ischemia detector comprises means for measuring sound absorption in heart tissue.

12. An implantable heart stimulator as claimed in claim 1 wherein said ischemia detector comprises means for measuring a difference between systolic and diastolic pressures respectively in successive heartbeats, and for comparing a difference obtained from one heartbeat to a difference obtained from a next successive heartbeat.

13. An implantable heart stimulator as claimed in claim 1 wherein said ischemia detector comprises a flow sensor which identifies cardiac output.

14. An implantable heart stimulator as claimed in claim 1 wherein said ischemia detector comprises means for sensing a patient workload and means for sensing patient respiration, and means for detecting a state of ischemia dependent on an occurrence of a predetermined relation between said workload and said respiration.

15. An implantable heart stimulator as claimed in claim 1 wherein said ischemia detector comprises means for sensing repolarization of a heart and means for sensing patient workload, and means for identifying a state of ischemia from an occurrence of a predetermined relation between said repolarization and said workload.

16. An implantable heart stimulator as claimed in claim 1 wherein said means for controlling comprises means for lowering said maximum allowable stimulation rate to a stimulation rate in a range between 100 and 110 stimulation pulses per minute.

17. An implantable heart stimulator as claimed in claim 16 wherein said means for controlling comprises means for maintaining said maximum allowable stimulation rate at a lowered rate for at least as long as said state of ischemia is present.