Integrated fluorescence-based biochemical sensor
First Claim
1. A sensor assembly comprising:
- a platform having an upper surface and a bottom surface;
a light source coupled to the upper surface of the platform;
a detector coupled to the upper surface of the platform adjacent the light source; and
an encapsulating housing extending over the platform and arranged to receive light from the light source;
where at least a portion of the exterior surface of the housing has a fluorescence emitting chemistry layer disposed upon it to form a sensing surface, the fluorescence emitting chemistry layer has a characteristic quality that interacts with a specific analyte sample to produce a change in the layer'"'"'s fluorescence emission;
where the light source emits light having an wavelength that excites the fluorescence emitting chemistry layer; and
where the housing has a substantially dome-shaped portion, the dome-shaped portion having a location and a radius such that the normal direction of the surface of the dome-shaped portion is oriented towards the detector, thereby increasing the amount of light emitted from the fluorescence emitting chemistry layer that impinges upon the detector.
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Accused Products
Abstract
An integrated biochemical sensor (200) for detecting the presence of one or more specific samples (240) having a device platform (355) with a light absorbing upper surface and input/output pins (375) is disclosed. An encapsulating housing (357) provides an optical transmissive enclosure which covers the platform (355) and has a layer of fluorescence chemistry on its outer surface (360). The fluorophore is chosen for its molecular properties in the presence of the sample analyte (240). The detector (370), light sources (365, 367, 407, 409) are all coupled to the platform (355) and encapsulated within the housing (357). A filter (375) element is used to block out unwanted light and increase the detector'"'"'s (370) ability to resolve wanted emission light.
56 Citations
9 Claims
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1. A sensor assembly comprising:
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a platform having an upper surface and a bottom surface; a light source coupled to the upper surface of the platform; a detector coupled to the upper surface of the platform adjacent the light source; and an encapsulating housing extending over the platform and arranged to receive light from the light source; where at least a portion of the exterior surface of the housing has a fluorescence emitting chemistry layer disposed upon it to form a sensing surface, the fluorescence emitting chemistry layer has a characteristic quality that interacts with a specific analyte sample to produce a change in the layer'"'"'s fluorescence emission; where the light source emits light having an wavelength that excites the fluorescence emitting chemistry layer; and where the housing has a substantially dome-shaped portion, the dome-shaped portion having a location and a radius such that the normal direction of the surface of the dome-shaped portion is oriented towards the detector, thereby increasing the amount of light emitted from the fluorescence emitting chemistry layer that impinges upon the detector.
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2. An integrated miniaturized sensor for indicating the presence of a given analyte sample comprising:
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a first light source; a sensing surface spatially arranged about the first light source to receive light; a detector mounted proximate the first light source and positioned to intercept light emitted from the sensing surface; and a light transmissive housing encapsulating the first light source and the detector; wherein, the exterior of the housing includes the sensing surface, and the housing is shaped to reflect light from the first light source away from the detector and toward an optical sink. - View Dependent Claims (3, 4, 5, 6)
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7. A fluorescence-based sensor for selectively identifying the presence of oxygen comprising:
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a platform having an upper and a bottom surface; a blue light emitting diode coupled to the upper surface of the platform; a photodiode coupled to the upper surface of the platform adjacent the diode; and an encapsulating housing extending over the upper surface of the platform, the housing having an outer portion with a ruthenium-based fluorescing chemistry thereon, the outer portion spatially arranged to; receive light from the diode, thereby exciting the fluorescing chemistry, reflect a substantial portion of the light received from the diode away from the photodiode; and allow light from the fluorescing chemistry to impinge upon the photodiode. - View Dependent Claims (8, 9)
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Specification