Diagnostic test carrier and methods in which it is used to determine an analyte
First Claim
1. A diagnostic test carrier for the determination of an analyte in a liquid sample, comprisinga supporting layer;
- a detection layer arranged on the supporting layer, said detection layer having reagents incorporated therewith for the detection of an analyte in a liquid sample; and
a network covering the detection layer, wherein the network is larger than the detection layer, the network extends beyond the detection layer, and the network is attached to the supporting layer, such that capillary liquid transport is possible from the detection layer to a part of the network which extends beyond the detection layer;
wherein the network is a multi-thread knitted fabric having, a thread of a first material located on a side of the fabric facing away from the detection layer, and a thread of a second material located on a side of the fabric facing the detection layer, and wherein the thread of the second material has a surface roughness which is greater than a surface roughness of the thread of the first material.
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Accused Products
Abstract
The invention concerns a diagnostic test carrier (1) containing a supporting layer (2) with a detection layer (3) arranged thereon containing the reagents required to determine an analyte in a liquid sample and a network (4) covering the detection layer (3) which is larger than the detection layer (3) and which is attached to the supporting layer (2), wherein the network (4) is a plied knitted fabric the threads of which are highly roughened on the side facing the detection layer (3) whereas the threads on the side of the knitted fabric which face away from the detection layer (3) are relatively smooth as well as the use of such a test carrier to determine an analyte in a liquid and the use of such a knitted fabric as a layer spreading liquid in a diagnostic test carrier. Moreover the invention concerns a method for the determination of an analyte in a liquid sample with the aid of a test carrier according to the invention.
38 Citations
30 Claims
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1. A diagnostic test carrier for the determination of an analyte in a liquid sample, comprising
a supporting layer; -
a detection layer arranged on the supporting layer, said detection layer having reagents incorporated therewith for the detection of an analyte in a liquid sample; and a network covering the detection layer, wherein the network is larger than the detection layer, the network extends beyond the detection layer, and the network is attached to the supporting layer, such that capillary liquid transport is possible from the detection layer to a part of the network which extends beyond the detection layer; wherein the network is a multi-thread knitted fabric having, a thread of a first material located on a side of the fabric facing away from the detection layer, and a thread of a second material located on a side of the fabric facing the detection layer, and wherein the thread of the second material has a surface roughness which is greater than a surface roughness of the thread of the first material. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23)
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24. A method of determining an analyte in a liquid sample, using a diagnostic test carrier comprising a supporting layer, a detection layer arranged on the supporting layer, said detection layer having reagents incorporated therewith for the detection of an analyte in a liquid sample, and a network covering the detection layer, wherein the network is a multi-thread knitted fabric having a thread of a first material located on a side of the fabric facing away from the detection layer, and a thread of a second material located on a side of the fabric facing the detection layer, wherein the thread of the second material has a surface roughness which is greater than a surface roughness of the thread of the first material, wherein the network is larger than the detection layer, the network extends beyond the detection layer, and the network is attached to the supporting layer such that capillary liquid transport is possible from the detection layer to a part of the network which extends beyond the detection layer, comprising
passing the liquid sample through the network to the detection layer, in a sufficient amount as to saturate the detection layer with liquid sample, with removal of excess liquid through capillary action into the region of the network which extends beyond the detection layer, to produce a detectable signal in the detection layer from reaction of the liquid sample with the reagents in the detection layer; - and
detecting the signal. - View Dependent Claims (25, 26, 27, 28, 29)
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30. A diagnostic test carrier for the determination of an analyte in a liquid sample, comprising
a supporting layer; -
a detection layer means, arranged on the supporting layer, for determining an analyte in a liquid sample; and a network means, covering the detection layer means, for allowing transport of the liquid sample therethrough from the exterior of the test carrier to the detection layer means, and for removing excess liquid from the detection layer means by capillary action.
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Specification