Calcium receptor-active molecules

  • US 6,031,003 A
  • Filed: 06/07/1995
  • Issued: 02/29/2000
  • Est. Priority Date: 08/23/1991
  • Status: Expired due to Term
First Claim
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1. A method of treating a patient having a disease or disorder which may be treated by a compound which modulates one or more activities of a calcium receptor in vitro comprising the step of administering to said patient a therapeutically effective amount of said compound, provided that if said compound is a calcimimetic compound, then said calcimimetic compound causes an increase in (Ca2+)i with an EC50 less than or equal to 5 μ

  • M as determined by measuring (Ca2+)i in bovine parathyroid cells loaded with fura-2 using the cytosolic Ca2+ cell assay, and if said compound is a calcilytic compound, then said calcilytic compound has an IC50 less than or equal to 5 μ

    M as determined by the calcilytic bovine parathyroid cell assay, wherein said compound is not protamine.

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