Protein complexes having Factor VIII:C activity and production thereof

  • US 6,060,447 A
  • Filed: 05/16/1995
  • Issued: 05/09/2000
  • Est. Priority Date: 05/19/1987
  • Status: Expired due to Term
First Claim
Patent Images

1. A composition comprising Factor VIII:

  • C proteins, wherein the Factor VIII;

    C proteins consist essentially of a first polypeptide comprising an amino acid sequence of the A domain of human Factor VIII;

    C as encoded by the polynucleotide present in plasmid pSVF8-200 (ATCC No.

         40190) or an amino acid sequence that differs therefrom in having not more than 10 number % amino acid substitutions, and a second polypeptide comprising an amino acid sequence of the C domain of human Factor VIII;

    C as encoded by the polynucleotide present in plasmid pSVF8-200 (ATCC No.

         40190) or an amino acid sequence that differs therefrom in having not more than 10 number % amino acid substitutions.

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