Sustained release delivery system

  • US 6,063,405 A
  • Filed: 01/08/1998
  • Issued: 05/16/2000
  • Est. Priority Date: 09/29/1995
  • Status: Expired due to Term
First Claim
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1. A method for making a sustained release delivery system which comprises:

  • blending an aqueous solution of a negatively charged polymer selected from the group consisting of hyaluronic acid, hyaluronic acid salt and mixtures thereof with an aqueous solution of a nonionic polymer selected from the group consisting of hydroxyethylcellulose, hydroxypropylcellulose and mixtures thereof to form a stable polymer matrix;

    sterilizing the stable polymer matrix; and

    wherein said stable polymer matrix continuously releases an active therapeutic drug for at least 24 hours when administered to an animal;

    wherein the molar ratio of the negatively charged polymer to the nonionic polymer 1;

    0.5 to 2.

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