Non-invasive measurement of blood glucose using instruments that have less precise detection capability
First Claim
1. A method for increasing an accuracy characteristic of a quantitative measurement instrument for measuring a blood analyte concentration, said method comprising:
- obtaining an energy absorption measurement through a body part of an individual;
determining an elapsed time since a last intake of nutrients by said individual which results in an increase of said blood analyte of at least a minimum predetermined amount;
calculating a correction factor based on said elapsed time from said last intake of nutrients; and
adding said correction factor to a regression analysis equation, wherein said regression analysis equation yields a predicted value of said blood analyte concentration.
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Abstract
A method and apparatus are disclosed for improving an accuracy characteristic of a quantitative measurement instrument for measuring a blood analyte concentration by using lower precision sensor devices. One embodiment of the method includes calculating a correction factor based on an elapsed time from a last meal and a substantially typical rise and fall pattern of blood analyte concentrations in the bloodstream. The correction factor is part of a regression analysis equation employed by the blood analyte measurement instrument. A second embodiment includes a method whereby a series of indicator variables are allocated based on the elapsed time from a last meal, and uses the indicator variables in a regression analysis equation. An apparatus having an introducer means for introducing an energy into blood present in a body part of a subject, a detector for detecting the energy emerging from the body part, with the detector producing an electrical signal indicative of the emerging energy, an input element for entering a time from a last meal of the subject, a storage element for storing a regression equation and a correction factor, and a processor for using the regression equation and the correction factor to yield a predicted value of the blood analyte concentration.
45 Citations
32 Claims
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1. A method for increasing an accuracy characteristic of a quantitative measurement instrument for measuring a blood analyte concentration, said method comprising:
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obtaining an energy absorption measurement through a body part of an individual; determining an elapsed time since a last intake of nutrients by said individual which results in an increase of said blood analyte of at least a minimum predetermined amount; calculating a correction factor based on said elapsed time from said last intake of nutrients; and adding said correction factor to a regression analysis equation, wherein said regression analysis equation yields a predicted value of said blood analyte concentration. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10)
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11. A method for increasing an accuracy characteristic of a quantitative measurement instrument for measuring a blood analyte concentration, said method comprising:
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obtaining an energy absorption measurement through a body part of an individual; determining an elapsed time since a last meal; and allocating a plurality of indicator variables to form a regression analysis equation based on said elapsed time since said last meal, wherein said regression analysis equation yields a predicted value of said blood analyte concentration. - View Dependent Claims (12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25)
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26. A quantitative measurement instrument for non-invasive measurement of a blood analyte concentration, comprising:
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introducing means including an energy source for introducing energy into blood present in a body part of a subject; detector circuit means for detecting said energy emerging from said body part, said detector circuit means producing a first electrical signal indicative of said energy emerging from said body part; input means for entering a time from a last intake of nutrients by said subject; storage means for storing a regression equation and a correction factor, said correction factor having a value dependent on said entered time from a last intake of nutrients; and processing means for processing said first electrical signal by using said regression equation and said correction factor to yield a predicted value of said blood analyte concentration, with said correction factor increasing an accuracy characteristic of said quantitative measurement instrument, by taking into account the elapsed time of said last intake of nutrients in said regression equation. - View Dependent Claims (27, 28, 29, 30, 31)
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32. A method for increasing an accuracy characteristic of a quantitative measurement instrument which utilizes a regression analysis equation for measuring a blood analyte concentration, said method comprising:
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obtaining an energy absorption measurement through a body part of an individual; determining an elapsed time since a last intake of nutrients by said individual which results in an increase of said blood analyte of at least a minimum predetermined amount; and modifying said regression analysis equation as a function of said elapsed time so as to obtain a blood analyte concentration measurement having increased accuracy by taking into account said last intake of nutrients.
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Specification