Monolithic tablet for controlled drug release

  • US 6,090,411 A
  • Filed: 03/09/1998
  • Issued: 07/18/2000
  • Est. Priority Date: 03/09/1998
  • Status: Expired due to Term
First Claim
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1. A monolithic controlled release drug delivery tablet for improving linearity of drug delivery over a sustained period of time comprising a hydrophilic swellable polymeric matrix;

  • a pharmaceutically effective amount of an active agent whose degree of solubilization is substantially independent of pH over a pH in the range of pH 1.5 to pH 7 .5 dispersed in said matrix, andan inorganic salt dispersed in said matrix at a concentration in the range of 50% to 100% by weight of the polymeric matrix, in which upon exposure to an aqueous medium, said salt causes a hardened boundary around the periphery of the matrix, said boundary sequentially progressing inwardly toward the center thereof as said aqueous medium permeates the matrix, said hardened boundary limiting the rate at which the pharmaceutically active agent in said matrix is released from the tablet,with the proviso that said tablet does not include polyacrylic acid or its pharmaceutically acceptable salt and said tablet is a compressed blend of homogeneous powders comprising said polymeric matrix, said active agent, and said salt.

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