Murine monoclonal antibody binding TNF.alpha.

  • US 6,090,923 A
  • Filed: 11/13/1991
  • Issued: 07/18/2000
  • Est. Priority Date: 12/20/1984
  • Status: Expired due to Term
First Claim
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1. A monoclonal antibody which specifically binds a human cytotoxin having a molecular weight of about 17,500 as determined by polyacrylamide gel electrophoresis, said cytotoxin being obtainable from stimulated human monocytes, said cytotoxin being further characterized by exhibiting a cytotoxic effect on cycloheximide-sensitized SV-80 cells and by being obtainable in a state of enhanced purity by adsorption of the cytotoxin from an impure preparation onto controlled pore glass beads, and subsequent desorption of the cytotoxin in a state of enhanced purity.

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