Solid .alpha.-phenyl-2-piperidine acetate free base, its preparation and use in medicine
DCFirst Claim
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1. The compound methyl α
- -phenyl-2-piperidine acetate free base, in solid form and having a melting point of 41-42°
C.
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Abstract
Methyl α-phenyl-2-piperidine acetate (free base) is disclosed as a crystalline solid, together with a method for its preparation; its use in medicine, in particular as a stimulant for the central nervous system; and pharmaceutical formulations comprising the compound, particularly transdermal patches.
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10 Claims
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1. The compound methyl α
- -phenyl-2-piperidine acetate free base, in solid form and having a melting point of 41-42°
C. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8)
- -phenyl-2-piperidine acetate free base, in solid form and having a melting point of 41-42°
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9. A process for preparing methyl α
- -phenyl-2-piperidine acetate (free base), which process comprises the steps of;
(i) stirring methyl α
-phenyl-2-piperidine acetate hydrochloride in a suitable organic solvent and aqueous base;(ii) evaporating the organic layer to leave an oil which solidifies on standing; and (iii) dissolving the crude solid in an organic solvent, cooling to less than 10°
C. and seeding with crude solid whilst continuing stirring. - View Dependent Claims (10)
- -phenyl-2-piperidine acetate (free base), which process comprises the steps of;
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