Receptors as novel inhibitors of vascular endothelial growth factor activity and processes for their production

  • US 6,100,071 A
  • Filed: 05/07/1996
  • Issued: 08/08/2000
  • Est. Priority Date: 05/07/1996
  • Status: Expired due to Term
First Claim
Patent Images

1. A VEGF receptor protein that is capable of binding to VEGF and thereby exerting an inhibitory effect thereon, said VEGF receptor protein comprising tyrosine kinase receptor-derived immunoglobulin-like domains 1, 2 and 3, wherein said tyrosine kinase receptor-derived immunoglobulin-like domain 1 comprises an amino acid sequence selected from the group consisting of:

  • (a) amino acids 32-128 of the flt-1 tyrosine kinase receptor shown in FIG. 1 (SEQ ID NO;

    1);

    (b) an amino acid sequence consisting essentially of the Ig-like domain 1 of the flt-1 tyrosine kinase receptor;

    (c) amino acids 32-118 of the KDR tyrosine kinase receptor shown in FIG. 1 (SEQ ID NO;

    2); and

    (d) an amino acid sequence consisting of the Ig-like domain 1 of the KDR tyrosine kinase receptor;

    wherein said tyrosine kinase receptor-derived immunoglobulin-like domain 2 comprises an amino acid sequence selected from the group consisting of;

    (e) amino acids 134-226 of the flt-1 tyrosine kinase receptor shown in FIG. 1 (SEQ ID NO;

    1);

    (f) an amino acid sequence consisting essentially of the Ig-like domain 2 of the flt-1 tyrosine kinase receptor;

    (g) amino acids 124-220 of the KDR tyrosine kinase receptor shown in FIG. 1 (SEQ ID NO;

    2); and

    (h) an amino acid sequence consisting essentially of the Ig-like domain 2 of the KDR tyrosine kinase receptor; and

    wherein said tyrosine kinase receptor-derived immunoglobulin-like domain 3 comprises an amino acid sequence selected from the group consisting of;

    (i) amino acids 232-331 of the flt-1 tyrosine kinase receptor shown in FIG. 1 (SEQ ID NO;

    1);

    (j) an amino acid sequence consisting essentially of the Ig-like domain 3 of the flt-1 tyrosine kinase receptor;

    (k) amino acids 226-327 of the KDR tyrosine kinase receptor shown in FIG. 1 (SEQ ID NO;

    2); and

    (l) an amino acid sequence consisting essentially of the Ig-like domain 3 of the KDR tyrosine kinase receptor; and

    wherein said VEGF receptor protein possesses at least one of (a), (b), (e), (f), (i) or (j) and at least one of (c), (d), (g), (h), (k) or (l).

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