Compositions, apparatus and methods for facilitating surgical procedures

• US 6,101,412 A
• Filed: 12/21/1999
• Issued: 08/08/2000
• Est. Priority Date: 08/08/1997
• Status: Expired due to Term

• Current Assignee: Duke University
• Original Assignee: Duke University
• Inventors: Duhaylongsod, Francis G.
• Primary Examiner(s): KRASS, FREDERICK F
• Application Number:
  US09/469,956
• Time in Patent Office: 231 Days
• Field of Search: 128/898, 607/2, 607/3, 607/9, 607/10, 607/11, 607/16, 607/30
• US Class Current: 607/2
• CPC Class Codes: A61K 2300/00 Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
• CPC Class Codes: A61K 31/00 Medicinal preparations containing organic active ingredients
• CPC Class Codes: A61K 31/135 having aromatic rings , e.g. ketamine, nortriptyline methadone A61K31/137
• CPC Class Codes: A61K 31/22 of acyclic acids, e.g. pravastatin
• CPC Class Codes: A61K 31/27 of carbamic or thiocarbamic acids, meprobamate, carbachol, neostigmine
• CPC Class Codes: A61K 31/445 Non condensed piperidines, e.g. piperocaine
• CPC Class Codes: A61K 45/06 Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
• CPC Class Codes: A61M 2210/125 Heart
• CPC Class Codes: A61P 9/00 Drugs for disorders of the cardiovascular system
• CPC Class Codes: A61P 9/04 Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure

Abstract

Methods are provided for conducting surgical procedures in a patient wherein, during the surgical procedure, autonomous ventricular electrical conductivity and escape beats are reversibly and transiently suppressed to facilitate the surgical procedure. Also provided are compositions which are capable of inducing ventricular asystole in a patient. The compossitions may include an AV node blocker. In one embodiment, compositions including an atrioventricular (AV) node blocker and a β-blocker are provided, wherein the β-blocker is present in an amount sufficient to substantially reduce the amount of AV node blocker required to induce ventricular asystole in the patient. The compositions and methods may be used for inducing temporary ventricular asystole in a beating heart, and to facilitate the performance of a variety of surgical techniques, including minimally invasive microsurgical techniques. Methods for performing a surgical procedure on a human patient are provided wherein a composition capable of inducing transient reversible ventricular asystole is administered to the heart, for example by intracoronary injection. The heart then is electrically paced using an electrical pacing stysem, thereby to maintain the patient'"'"'s blood circulation. The electrical pacing then is selectively intermittently stopped to allow ventricular asystole to occur, and the steps of the surgical or therapeutic procedure, such as suturing, are conducted during the time that the electrical pacing is intermittently stopped. The methods and comositions advantageously may be used in a range of different surgical procedures including cardiac, vascular and neurosurgical procedures.

Claims

1. A method of inducing a period of reversible ventricular asystole to facilitate a medical procedure, while maintaining the ability of the heart to be electrically paced, comprising:

inducing third-degree AV block of the heart in a patient by vagal nerve stimulation; and

administering to said patient at least one compound which is capable of substantially suppressing ectopic ventricular beats in the heart during asystole.

2. The method of claim 1 wherein the compound is a B-blocker.

3. The method of claim 2 wherein the B-blocker is propranolol.

4. The method of claim 2 wherein the B-blocker is selected from the group consisting of atenolol, acebutolol, labetalol, metoprolol, nadolol, oxprenolol, penbutolol, pindolol, sotalol, timolol, celiprolol, betaxolol, bevantolol, bisoprolol, esmolol, alprenolol, carterolol and teratolol.

5. The method of claim 2 wherein the B-blocker is administered to the heart of the patient.

6. The method of claim 2 wherein the B-blocker is administered to the left or right coronary artery of the patient.

7. The method of claim 2 wherein the B-blocker is administered to the patient prior to inducing third-degree AV block of the heart.

8. The method of claim 1 wherein the medical procedure is a surgical procedure.

9. The method of claim 1 wherein the medical procedure is a coronary artery bypass procedure.

10. The method of claim 1 wherein the medical procedure is an imaging procedure.

11. A method of inducing a period of reversible ventricular asystole in a patient to facilitate a medical procedure comprising:

inducing third-degree AV block of the heart by vagal nerve stimulation; and

administering a B-blocker to the heart of the patient during asystole.

12. A method of inducing a period of reversible ventricular asystole to facilitate a medical procedure, while maintaining the ability of the heart to be electrically paced, comprising:

inducing third-degree AV block of the heart in a patient by direct electrical stimulation;

and administering to said patient at least one compound which is capable of substantially suppressing ectopic ventricular beats in the heart during asystole.

13. The method of claim 12 wherein the compound is a B-blocker.

14. The method of claim 13 wherein the B-blocker is propranolol.

15. The method of claim 13 the B-blocker is selected from the group consisting of atenolol, acebutolol, labetalol, metoprolol, nadolol, oxprenolol, penbutolol, pindolol, sotalol, timolol, celiprolol, betaxolol, bevantolol, bisoprolol, esmolol, alprenolol, carterolol and teratolol.

16. The method of claim 13 wherein the B-blocker is administered to the heart of the patient.

17. The method of claim 13 wherein the B-blocker is administered to the left or right coronary artery of the patient.

18. The method of claim 13 wherein the B-blocker is administered to the patient prior to inducing third-degree AV block of the heart.

19. The method of claim 12 wherein the medical procedure is a surgical procedure.

20. The method of claim 12 wherein the medical procedure is a coronary artery bypass procedure.

21. The method of claim 12 wherein the medical procedure is an imaging procedure.

22. A method of inducing a period of reversible ventricular asystole in a patient to facilitate a medical procedure comprising:

inducing third-degree AV block of the heart by direct electrical stimulation; and

administering a B-blocker to the heart of the patient during asystole.