Implant

• US 6,110,204 A
• Filed: 02/09/1998
• Issued: 08/29/2000
• Est. Priority Date: 02/22/1995
• Status: Expired due to Term

• Current Assignee: Tinox AG
• Original Assignee: Huber & Schussler
• Inventors: Lazarov, Miladin, Mayer, Isabella
• Primary Examiner(s): Yu, Mickey
• Assistant Examiner(s): Koh, Choon P.
• Application Number:
  US08/913,268
• Time in Patent Office: 932 Days
• Field of Search: 623/11, 623/16, 623/18, 623/12, 606/76, 604/265, 427/2.24, 427/453, 427/126.3, 428/304.4, 428/315.5
• US Class Current: 623/11.11
• CPC Class Codes: A61F 2/04 Hollow or tubular parts of organs, e.g. bladders, tracheae, bronchi or bile ducts A61F2/18, A61F2/20 take precedence; devices, other than stent-grafts, providing patency to, or preventing collapsing of, tubular structures of the body other than stent-grafts, e.g. stents A61F2/82; instruments specially adapted for placement or removal of stents or stent-grafts A61F2/95
• CPC Class Codes: A61F 2/24 Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body
• CPC Class Codes: A61F 2/82 Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents stent-grafts for tubular structures of the body other than blood vessels A61F2/04; stent-grafts for blood vessels A61F2/07; instruments specially adapted for placement or removal of stents or stent-grafts A61F2/95; for closing wounds, or holding wounds closed A61B17/04 - A61B17/115; dilators A61M29/00
• CPC Class Codes: A61L 27/306 Other specific inorganic materials not covered by A61L27/303 - A61L27/32
• CPC Class Codes: A61L 29/106 Inorganic materials other than carbon
• CPC Class Codes: A61L 31/088 Other specific inorganic materials not covered by A61L31/084 or A61L31/086
• CPC Class Codes: C23C 14/0676 Oxynitrides
• CPC Class Codes: C23C 28/04 only coatings of inorganic non-metallic material
• CPC Class Codes: C23C 28/044 coatings specially adapted for cutting tools or wear applications
• CPC Class Codes: C23C 30/00 Coating with metallic material characterised only by the composition of the metallic material, i.e. not characterised by the coating process C23C26/00, C23C28/00 take precedence
• CPC Class Codes: Y10T 428/249953 Composite having voids in a component [e.g., porous, cellular, etc.]
• CPC Class Codes: Y10T 428/249978 Voids specified as micro

Abstract

The present invention relates to an implant for use in the human body, an implant substrate being coated with a material which contains chemical compounds between one or more metals (M) of group IV A of the periodic system, nitrogen (N) and oxygen (O), 2 to 45% of the volume in the coating material being formed by voids whose sizes range from (0.4 nm)³ to (50 nm)³, and the remaining volume having a composition of a metal of group IV A of the periodic system to nitrogen to oxygen of 1:(0.1 to 1.7):(0.1 to 1.7), a material having formula MN_x O_y (wherein x,y=0.1-1.7) resulting.

The invention also relates to the use of this implant for implantation into the animal or human body.

Claims

1. An implant, comprising a substrate coated with a thin layer of a coating material, wherein said coating material comprises one or more metals (M) of group IV A of the periodic table, nitrogen (N) and oxygen (O), and wherein 2 to 45% of the volume in the coating material is formed by voids whose sizes range from (0.4 nm)³ to (50 nm)³ and the remaining volume comprises a composition of a metal of group IV A of the periodic table, nitrogen and oxygen in a ratio of 1:

(0.1 to 1.7);

(0.1 to 1.7), such that a material having the formula MN_x O_y wherein x,y=0.1-1.7 results.

2. The implant according to claim 1, wherein the coating material further comprises one or more of the following chemical compounds:

MN_x wherein x=0.7 to 1.2

MO_x wherein x=0.7 to 1.2

Magnelli phases of the M--O system (M_n O_2n-1)

MO₂

M₂ N

wherein M is a metal of group IV A of the periodic table.

3. The implant according to any one of claims 1 to 2, wherein the coating material contains small amounts of carbon compounds of a metal of group IV A of the periodic table.

4. The implant according to any one of claim 1 or 2, wherein the metals (M) of group IV A of the periodic table, nitrogen (N) and oxygen (O) may occur in the coating material in crystalline or amorphous form.

5. The implant according to any one of claim 1 or 2, wherein the real part of the refractive index of the coating material for the X-ray wavelength of 0.0709 nm ranges from 0.9999984 to 0.9999973.

6. The implant according to any one of claim 1 or 2, wherein the mass density of the coating material ranges from 3.5 to 5.4 g/cm³.

7. The implant according to any one of claim 1 or 2, further comprising at least one compound selected from the group consisting of niobium, tantalum, tungsten, molybdenum and alloys thereof.

8. The implant according to any of claim 1 or 2, wherein the coating material further comprises hydrogen.

9. The implant according to any one of claim 1 or 2, wherein the layer thickness of the coating material on the substrate ranges from 3 nm to 3 mm.

10. The implant according to any one of claim 1 or 2, wherein the specific resistance ranges from 30 to 300000 μ

Ω

cm.

11. The implant according to any of claim 1 or 1, wherein the coating material is applied as a thin layer onto a rough substrate surface wherein the roughness is characterized by a random distribution of deviations from a mean level wherein a standard deviation of the distribution ranges from 0 to 1500 μ

m.

12. The implant according to any one of claim 1 or 2, wherein the thin coating layer is coated with at least one further thin layer comprising one or more oxides selected from the group consisting of SiO₂, TiO₂, ZrO₂, HfO₂, Al₂ O₃ Y₂ O₃ , niobium oxide molybdenum oxide, tungsten oxide and tantalum oxide.

13. The implant according to any one of claim 1 or 2, wherein at least one further thin layer, made of a metal or a semi-conductor is introduced between the substrate and the coating.

14. The implant according to any one of claim 1 or 2, wherein the coating material is applied onto a metallic substrate comprising molybdenum, silver, gold, copper, aluminum, tungsten, nickel, chromium, zirconium, titanium, hafnium, tantalum, niobium, vanadium, iron and one or more alloys thereof.

15. The implant according to any one of claim 1 or 2, wherein the coating material is applied onto a plastics substrate comprising a polyester, a polyamide, a polyurethane (PUR), a polyethylene (PE), a polytetrafluoroethylene (PTFE) or DACRON^R.

16. The implant according to any one of claim 1 or 2, wherein the voids range from (0.4 nm)³ to (50 nm)³ and the coating material has voids greater than (500 nm)³.