Ultrasound image assisted administering of medication

• US 6,126,600 A
• Filed: 05/04/1998
• Issued: 10/03/2000
• Est. Priority Date: 12/02/1994
• Status: Expired due to Term

• Current Assignee: Koninklijke Philips N.V.
• Original Assignee: John T. Oxaal, Olaf T Von Ramm, Smith, Robert Samuel
• Inventors: Smith, Robert Samuel, Von Ramm, Olaf T, Oxaal, John T
• Primary Examiner(s): Kamm, William E.
• Assistant Examiner(s): PATEL, MAULIN M
• Application Number:
  US09/072,732
• Time in Patent Office: 883 Days
• Field of Search: 600/437, 600/447, 600/439, 600/443, 604/19, 604/22, 604/20
• US Class Current: 600/439
• CPC Class Codes: G01S 15/8906 Short-range imaging systems; Acoustic microscope systems using pulse-echo techniques
• CPC Class Codes: G01S 7/52034 Data rate converters

Abstract

An apparatus and method for injecting a drug into a precisely selected location in a patient'"'"'s body which is a combination scanner and drug injector. The scanner is a planar array of ultrasonic transducers which transmits a focused ultrasonic beam over the entire region of interest. The injector is preferably a hypodermic syringe mounted with the array on a base. The syringe is mounted to slide between one position where the injector conduit is retracted from the patient and another position where the adjustably positioned exit end of the conduit is in the desired location for injection of the drug. As the operator holds the scanner-injector against the patient'"'"'s body with injector conduit retracted, he views on a monitor screen a virtual image of the conduit which is the image of the conduit after the conduit is injected into the body. The operator electronically adjusts the length of the virtual image and adjusts the position of the scanner-injector so that the exit tip of the virtual image is located at the desired location of the image of the region on the screen. Then the conduit is inserted into the body up to a length where the exit tip of the injector is at the desired location. Then the drug is injected into the patient. In another application of the apparatus and methods of the invention, a vacuum source is attached to the injector conduit and the device is used to aspirate fluids. instead of a drug In another embodiment, a portion of the ukltrasonic beam is focused on the region of interest before and during insertion of the conduit and drug to facilitate entry of the drug into the region of interest.

Claims

1. An apparatus for one of:

(i) injecting drugs into a desired location of a region in a patient;

(ii) aspirating a body fluid from a desired location of a region in a patient;

which comprises;

an injector means having an injector conduit with an entry end and an exit end for injecting said conduit into said patient;

means for one of;

(i) injecting drug through said conduit from said entry end to said exit end;

(ii) aspirating fluid through said conduit from said exit end to said entry end;

display means for displaying an image of said region on a video monitor;

means for displaying on screen simultaneously with said image of said region a virtual image of said injector conduit;

said virtual image displayed at a location relative to said image of said region corresponding to where said exit end of said conduit is located when said conduit is injected into said region providing that an operator is enabled to view said image of said region and adjust a position of said injector means relative to said desired location prior to injecting said conduit thereby ensuring that, when said conduit is injected into said region and one of;

(i) said drug is injected through said conduit, said drug will enter said region at said desired location;

(ii) said body fluid is aspirated through said conduit, said body fluid is aspirated from said region at said desired location.

2. The apparatus of claim 1 wherein said means for displaying comprises means for simultaneously displaying in real time and image of at least one cross section of variable thickness of said refion, said at least one cross section being any cross section of said object and selected by a viewer viewing said displayed image.

3. The apparatus of claim 2 wherein said region has a range of accoustical properties and said means for displaying an image of said region comprises:

radiating means adapted for radiating said region with a first plurality of sonic beams such that each said beam generates a wave reflected from a second plurality of locations distributed in said region;

resolving means for resolving said wave into echo data, each said datum of said echo data representing intensity of reflection of one of said first plurality of sonic beams from one of said second plurality of locations in said object respectively;

means for selecting a set of echo data taken from a third plurality of locations in said second plurality of locations corresponding to said any cross section selected by said viewer;

converting means for converting said set of echo data to brightness signals to said screen whereby said image of said selected cross section is displayed on said monitor screen.

4. An apparatus as in claim 3 wherein said means for radiating includes:

array means having a radiating surface adapted for radiating said sonic pulsed beam from said radiating surface in any one direction of said first plurality of transmit directions, each transmit direction definable by azimuthal and elevational angular coordinates

means for successively pulsing said array means to emit said first plurality of transmitted beams;

means for controlling each said transmit directions to lie in a repeted pattern of transmit directions such as to intersect said object.

5. An apparatus as in claim 4 wherein said array means comprises:

a hand held base having a face;

an array of ultrasonic transducer means mounted on said face for forming an ultrasonic radiating surface;

said transducers arranged to form at least one column of transducers perpendicular to at least one row of transducers; and

said conduit being mounted together with said array on said hand held base positionable with said conduit lying along a fixed center line oblique to said array in one position where said conduit is retracted from a body of said patient when said array is flush against said body and another position where said conduit is extended into said body by a length when said array is flush against said body;

means for selecting said length whereby an operator is enabled to view said image of said region and said virtual image and position said array with said exit opening of said virtual image positioned at said image of said desired location of said region prior to injecting said conduit into said body of said patient.

6. An apparatus as in claim 5 wherein said means for displaying said image of said selected cross section comprises:

a memory means having addresses for storing said set of echo data corresponding to said selected cross section;

means for addressing each said address to store echo data at a time selected to coincide with a beam orientation such that each address in memory corresponds to a position of one of said locations in said region relative to a position of said array whereby an operator is enabled to position said image of said selected cross section at any location on said screen by adjusting a position of said array; and

said means for displaying said virtual image of said conduit comprises data stored in said memory that produces a bright line on said screen corresponding to conduit addresses of locations lying along a line of extension of said injector conduit from said array;

said means for selecting length including means for displaying brightness on said screen includes means for selecting said conduit addresses in memory corresponding to said length whereby said virtual image of said conduit is enabled to be positioned relative to said image of said region by said operator adjusting a position of said array on said body of said patient and adjusting a length of said line until an end of said line coincides with a location in said image of said region corresponding to where it is desired to inject said drug in said region whereby said operator is enabled to insert said conduit into said region and inject said drug into said desired location.

7. The apparatus of claim 5 wherein said injector comprises:

a hypodermic syringe supported on said base and with sad conduit including a hypodermic needle of said hypodermic syringe;

said syringe having a barrel and plunger means for one of;

(i) forcing drug in said barrel through said conduit and out of said exit end of said conduit;

(ii) aspirating fluid from said region into said exit end through said conduit and out of said entry end into said barrel.

8. The apparatus of claim 7 which comprises:

linear stepper actuator means coupled between said plunger and said barrel for controlling a position of said plunger in said barrel;

means for applying a signal to said actuator whereby an amount of one of

(i) drug injected into;

(ii) fluid aspirated from;

said region is selectable.

9. The apparatus of claim 7 which comprises:

linear stepper actuator means coupled between said base and said syringe for controlling injection of said conduit into said body of said patient;

means for applying a signal to said actuator whereby said length of said conduit injected into said patient is selectable.

10. The apparatus of claim 7 which comprises a first ultrasonic transducer means coupled to said barrel for transmitting ultrasound energy into said drug passing through said conduit.

11. The apparatus of claim 7 which comprises a second ultrasonic transducer means coupled to said syringe for transmitting uktrasonic energy to said conduit while said conduit is being injected into said patient.

12. The apparatus of claim 5 comprising means for directing an ultrasonic beam continuously on said region of said patient during a period being at least one of:

(i) a period before injecting said conduit into said body;

(ii) a period while injecting said conduit into said body;

(iii) a period before injecting said drug through said conduit into said body;

(iii) a period while injecting said drug into said region;

(iv) a period after injecting said drug into said region.

13. A method for injecting a drug into a desired location of a region in a patient which includes the steps in operable order:

(a) providing a device which comprises;

(i) an injector means having an injector conduit with an exit end for injecting said conduit into said patient;

(ii) display means for displaying an image of said region on a video monitor;

(iii) means for diplaying on said screen simultaneously with said image of said region a virtual image of said injector conduit;

(b) applying said device to display said image and said image of said region to provide that said virtual image is in a location relative to said image of said region correspondint to where said exit end of said conduit is located when said conduit is injected into said region proviing that an operator is enabeled to view said image of said region and said virtyual image and adjust a position of sid injector means relative to said desired location prior to injecting said conduit thereby ensuruing that, when said conduit is injected into said region, and said drug is injected through said conduit, said drug will enter said region at said desired location,

(c) inserting said conduit into said body with said exit end positioned at said location;

(d) injecting said drug into said location.

15. The method of claim 13 which includes at least one of the steps:

(i) directing an ultrasonic wave onto said location before injecting said conduit into said region;

(ii) directing an ultrasonic wave onto said location while injecting said conduit into said region;

(iii) directing an ultrasonic wave onto said location before one of aspirating said fluid and injecting said drug into said region;

(iv) directing an ultrasonic wave onto said location before one of aspirating said fluid and injecting said drug through said conduit into said region.

14. A method for one of:

(i) injecting a drug into

(ii) aspirating a fluid from

a desired location of a region in a patient which includes the steps in operable order

(a) providing a device which comprises;

(i) an injector means having an injecter conduit with an exit end for injecting said conduit into said patient;

(ii) display means for displaying an image of said region on a video monitor;

(iii) means for displaying on said screen simultaneously with said image of said region a virtual image of said injector conduit;

(b) applying said device to display said virtual image and said image of said region such that said virtual image is in a location relative to said image of said region corresponding to where said said exit end of said conduit is located when said conduit is injected into said region providing that an operator is enabled to view said image of said region and said virtual image and adjust a position of said injector means relative to said desired location prior to injecting said conduit thereby ensuring that, when said said conduit is injected into said region and one of;

(i) said drug is injected through said conduit, said drug will enter said region at said desired location;

(ii) said fluid is aspirated through said conduit from said region at said desired location;

(c) inserting said conduit into said body with said exit end positioned at said location;

(d) one of;

(i) injecting said drug into said location;

(ii) aspirating fluid from said desired location.