Chimeric adenoviral coat protein and methods of using same
First Claim
1. A chimeric adenovirus coat protein, comprising a non-native amino acid sequence, which comprises a non-hexon amino acid sequence, wherein said chimeric adenovirus coat protein has a decreased ability or inability to be recognized by a neutralizing antibody directed against a corresponding wild-type adenovirus coat protein.
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Abstract
The present invention provides a chimeric adenoviral coat protein (particularly a chimeric adenovirus hexon and/or fiber protein). The chimeric adenovirus coat protein has a decreased ability or inability to be recognized by a neutralizing antibody directed against the corresponding wild-type adenovirus coat protein. The invention also provides an adenovirus comprising a chimeric adenovirus coat protein, and methods of constructing and using such an adenovirus, for instance, in gene therapy.
119 Citations
48 Claims
- 1. A chimeric adenovirus coat protein, comprising a non-native amino acid sequence, which comprises a non-hexon amino acid sequence, wherein said chimeric adenovirus coat protein has a decreased ability or inability to be recognized by a neutralizing antibody directed against a corresponding wild-type adenovirus coat protein.
- 33. A chimeric adenovirus fiber or penton base protein comprising a nonnative amino acid sequence, wherein said chimeric adenovirus fiber or penton base protein has a decreased ability or inability to be recognized by a neutralizing antibody directed against a corresponding wild-type adenovirus fiber or penton base protein.
Specification