Transcorneal drug-release system
First Claim
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1. A transcorneal system for controlled transcorneal delivery of a medicament into a warm-blooded animal comprising:
- a) an active substance reservoir comprising a drug -containing liquid ;
b) a device, which device is provided with micro-blades which are capable of penetrating the stratum corneum of the animal and which device is also provided with a liquid-conveying means, whereby the device is connected to the reservoir via its liquid-conveying means to allow drug-containing liquid to pass from the reservoir to the micro-blades; and
c) a means for actively controlling the passing of drug-containing liquid from the reservoir to the micro-blades, wherein the means for actively controlling the passing of drug-containing liquid from the reservoir to the micro-blades is an integrated pump with integrated electronic controls.
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Abstract
The invention refers to a transcorneal system for the actively controlled transcorneal delivery of a medicament into a subject comprising an active substance reservoir and a device provided with a plurality of micro-pins or micro-blades adapted in use to penetrate the stratum corneum of the subject and connected with reservoir via a liquid conveying connection and thereby allow active substance to pass from the reservoir through capillary openings of the micro-pins or along the micro-blades into the subject.
366 Citations
21 Claims
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1. A transcorneal system for controlled transcorneal delivery of a medicament into a warm-blooded animal comprising:
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a) an active substance reservoir comprising a drug -containing liquid ; b) a device, which device is provided with micro-blades which are capable of penetrating the stratum corneum of the animal and which device is also provided with a liquid-conveying means, whereby the device is connected to the reservoir via its liquid-conveying means to allow drug-containing liquid to pass from the reservoir to the micro-blades; and c) a means for actively controlling the passing of drug-containing liquid from the reservoir to the micro-blades, wherein the means for actively controlling the passing of drug-containing liquid from the reservoir to the micro-blades is an integrated pump with integrated electronic controls. - View Dependent Claims (7, 9, 11, 13, 15, 17, 18, 19)
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2. A transcorneal system for controlled transcorneal delivery of a medicament into a warm-blooded animal comprising:
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a) an active substance reservoir comprising a drug-containing liquid; b) a device, which device is provided with a plurality of micro-pins which are capable of penetrating the stratum corneum and which micro-pins have capillary openings at both ends and hollow spaces within the micro-pins and which device is connected to the reservoir via the capillary opening at one end of each of the micro-pins and is adjacent the stratum corneum at the opposite end of each of the micro-pins; and c) a means for actively discharging the drug-containing liquid from the reservoir through the micro-pins, wherein the means for actively discharging the drug-containing liquid is an integrated pump with integrated electronic controls. - View Dependent Claims (3, 4, 5, 6, 8, 10, 12, 14, 16, 20, 21)
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Specification