Adaptive filtering of physiological signals using a modeled synthetic reference signal

• US 6,135,952 A
• Filed: 01/29/1999
• Issued: 10/24/2000
• Est. Priority Date: 03/11/1998
• Status: Expired due to Term

• Current Assignee: Siemens AG
• Original Assignee: Siemens Corporate Research Incorporated (Siemens AG)
• Inventors: Coetzee, Frans Martin
• Primary Examiner(s): WINAKUR, ERIC FRANK
• Application Number:
  US09/240,122
• Time in Patent Office: 634 Days
• Field of Search: 600/310, 600/322, 600/323, 600/330, 600/336
• US Class Current: 600/336
• CPC Class Codes: A61B 5/14551 for measuring blood gases
• CPC Class Codes: A61B 5/7257 using Fourier transforms
• CPC Class Codes: G06F 2218/02 Preprocessing
• CPC Class Codes: Y10S 128/901 Suppression of noise in electric signal

Abstract

An adaptive filtering method and apparatus for reducing the level of an undesired noise component in an acquired physiological signal having a desired signal component. The acquired physiological signal is applied to one input of the adaptive filter, and a synthetic reference signal that is modeled so as to exhibit a correlation with the desired signal component is applied to another input of the adaptive filter. Thereafter, in a feedback manner, the adaptive filter iteratively adjusts the modeled synthetic reference signal so as to progressively generate a more accurate approximation of the desired signal component in the adaptive filter, which approximation becomes a reconstruction of the acquired physiological signal wherein the level of the undesired noise component is reduced.

Claims

1. An oximeter for determining an estimate of the blood oxygen saturation level in the body of a patient, by processing red and infrared electrical signals acquired by a sensor arrangement upon application of red and infrared light towards a well perfused portion of the body of the patient, which electrical signals comprises a desired pulsatile component and an undesired noise component, comprising:

a sensor arrangement for acquiring red and infrared electrical signals;

a signal generator for operating independently of said acquired red and infrared electric signals, for providing a predetermined synthetic reference signal that is expected to exhibit a correlation with the desired pulsatile component of the acquired red and infrared electrical signals;

an adaptive filter arrangement having a first input responsive to said acquired red and infrared electrical signals, and a second input responsive to said synthetic reference signal, said adaptive filter arrangement operating in a feedback manner so as to iteratively adjust the applied synthetic reference signal so as to progressively generate as an output of the filter arrangement more accurate approximations of the desired pulsatile component of the acquired red and infrared electrical signals; and

a saturation estimate processor for processing said more accurate approximations of the desired pulsatile component of the acquired red and infrared electrical signals, to develop a saturation estimate of the blood oxygen saturation level in the body of the patient.

2. The apparatus of claim 1, wherein said saturation estimate processor comprises:

a normalizer stage, responsive to said more accurate approximations of the desired pulsatile component of the acquired red and infrared electrical signals, to develop a normal version of said electrical signals; and

a ratio calculator, responsive to said normal version of said electrical signals for developing a ratio value.

3. The apparatus of claim 2, further comprising:

a look-up-table, having an address input responsive to the ratio value, and an output for providing a value representative of the saturation estimate of the patient.

4. The apparatus of claim 3, further comprising:

a filter for determining a median value of a plurality of said saturation estimate values provided by said look-up-table, and

an integrator for integrating said median value over time.

5. The apparatus of claim 1, wherein said signal generator provides as said synthetic reference signal a predetermined kernel function intended to be representative of the phase and frequency of a pulsatile cycle of the desired signal component of the acquired electric signals.

6. The apparatus of claim 1, wherein said adaptive filter comprises:

a multistage lattice prediction filter for shifting and weighting of said synthetic reference signal to generate backward prediction error signals; and

a regressor processing stage for iteratively combining said acquired electric signals with shifted and weighted versions of said backward prediction error signals, to progressively build-up a reconstruction of the desired component of said acquired electric signals.

7. The apparatus of claim 1, including:

a confidence processor for processing the acquired electric signals to identify sections thereof having a high confidence of being relatively noise-free.

8. The apparatus of claim 7, further including:

an extraction processor responsive to the acquired electric signals and to the confidence processor, so as to only process said high confidence sections of the acquired electric signals, and in response to said processing develop a value that is used to adjust the generation of the synthetic reference signal so that it exhibits a greater correlation with the desired signal component of the acquired electric signals.

9. The apparatus of claim 8, wherein said confidence processor comprises:

a correlation detector for determining the correlation coefficient between the red and infrared acquired electric signals; and

an error code tagger responsive to said correlation coefficient for developing an error code stream that identifies sections of each of said acquired electric signals that exhibit a correlation coefficient that exceeds a predetermined threshold level as being relatively noise-free, and identifies sections of each of said acquired electric signals that exhibit a correlation coefficient that does not exceed the predetermined threshold level as being relatively noisy.

10. The apparatus of claim 9, wherein said confidence processor comprises:

an amplitude detector for subjecting said red and infrared acquired electric signals to an amplitude threshold test; and

a further error code tagger responsive to said amplitude detector for developing an error code stream that identifies sections of said red and infrared acquired electric signals that have an amplitude that do not exceed a predetermined amplitude threshold level as being relatively noise-free, and identifying sections of said red and infrared acquired electric signals that have an amplitude that do exceed the predetermined amplitude threshold level as being relatively noisy.

11. The apparatus of claim 10, wherein said extraction processor comprises:

an FFT processor responsive to said confidence processor, for processing only those sections of the red and infrared acquired electric signals that are identified to have a high confidence of being relatively noise-free, to develop a value representative of at least a fundamental frequency component of the desired signal component of the acquired electric signals, which value is used to adjust the modeling of the synthetic reference signal so as to increase its correlation with the desired signal component of the acquired electric signals.

12. The apparatus of claim 10, further including:

a morphological processor for processing the error code streams developed by said first-mentioned and said further error code taggers to increase the degree of confidence that sections of said red and infrared acquired electric signals identified as being relatively noise-free or relatively noisy have been correctly identified.