Antioxidant and/or antielastase composition based on lupine oil

• US 6,146,616 A
• Filed: 12/24/1998
• Issued: 11/14/2000
• Est. Priority Date: 04/24/1997
• Status: Expired due to Term

• Current Assignee: Laboratoires Expanscience
• Original Assignee: Laboratories Pharmascience
• Inventors: Montaudoin, Marie-Georgette, Rancurel, Alain, Msika, Philippe
• Primary Examiner(s): Dodson, Shelley A.
• Application Number:
  US09/202,959
• Time in Patent Office: 691 Days
• Field of Search: 424/400, 424/401, 424/59
• US Class Current: 424/59
• CPC Class Codes: A61K 2300/00 Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
• CPC Class Codes: A61K 36/48 Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
• CPC Class Codes: A61K 8/922 of vegetable origin
• CPC Class Codes: A61Q 17/04 Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
• CPC Class Codes: A61Q 19/00 Preparations for care of the skin
• CPC Class Codes: A61Q 19/001 Preparations for care of the lips
• CPC Class Codes: A61Q 19/08 Anti-ageing preparations

Abstract

The invention concerns an antioxidant and/or antielastase composition containing lupine oil or one or several fractions thereof, its use in cosmetics, pharmaceutics and as food additive. More particularly it concerns a composition containing a mixture of lupine oil and wheat germ concentrate, preferably in a proportion of 70 wt. % of lupine oil and 38 wt. % of wheat germ concentrate.

Claims

1. A composition comprising lupine oil or one or more of its fractions for use as an antioxidant and/or antielastase.

2. The composition of claim 1, wherein said lupine oil is obtained from lupine meal and/or seeds.

3. The composition of claim 1, wherein said lupine oil is obtained from a sweet lupine variety.

4. The composition of claim 3, wherein said lupine oil is obtained from lupinus albus.

5. The composition of claim 1, wherein said fraction is a lupine oil concentrate, obtained by molecular distillation of said oil.

6. The composition of claim 5, wherein said fraction is an unsaponifiable fraction contained in a concentrate obtained by molecular distillation of said oil.

7. The composition of claim 6 wherein the quantity by weight of the unsaponifiable fraction in the lupine oil concentrate is about 30 % to about 70 %.

8. The composition of claim 1, which contains a lupine oil fraction comprising phenol derivatives.

11. The composition of claim 1, comprising wheat germ oil or one or more fractions thereof.

12. The composition of claim 11, wherein said wheat germ oil fraction is a concentrate obtained by molecular distillation of said oil.

13. The composition of claim 12, wherein said wheat germ oil fraction is an unsaponifiable fraction contained in a concentrate obtained by molecular distillation of said oil.

14. The composition of claim 12, wherein said composition contains a wheat germ oil concentrate in the form of a mixture with lupine oil.

15. The composition of claim 14, wherein the amount by weight of concentrate of wheat germ oil and of lupine oil vary respectively between about 10% and about 90% and between about 90% and about 10% so that the amount of said wheat germ oil and lupine oil is 100% in total.

16. The composition of claim 15, wherein the quantities by weight of concentrate of wheat germ oil and of lupine oil are respectively 30% and 70%.

17. The composition of claim 1 wherein said use is selected from the group consisting of a cosmetic composition, an antioxidant, an anti-free radical agent, an antielastase agent, an agent for protecting against UVA and /or UVB, and an agent for protecting DNA against damage.

18. The composition of claim 1 which is a pharmaceutical further comprising a dermatological carrier.

19. The composition of claim 18 wherein said pharmaceutical prevents or treats the effects of UVA and/or UVB radiation on the skin at the epidermal, dermal, cellular or extracellular levels.

20. The composition of claim 18, wherein said pharmaceutical prevents or treats the effects of oxidation, of elastase and of free radicals on the skin.

21. The composition of claim 18, wherein said pharmaceutical is an agent having an activity of protecting DNA against damage.

22. The composition of claim 1 further comprising a physiologically acceptable vehicle.

23. The composition of claim 22, wherein said use is selected from the group consisting of use as an antisun product for protecting against UVB and/or A radiation and/or infrared radiation, a restructuring or toning cream, a cream, for the prevention and the regression of vibices, a nutritive cream, an antiwrinkle cream, a cream for combating aging of the skin, epidermis and dermis, a protective day cream, a contour cream for the lips and the eyes, and regenerative and protective lipsticks.

24. The composition of claim 23, which is formulated for topical use.

25. The composition of claim 24 wherein the total content by weight of lupine oil or the fractions thereof and wheat germ oil or fractions thereof of said composition is of the order of about 0.5% to about 10%.

26. Method of improving the appearance of an individual comprising administering on the skin surface of an individual the composition of claim 1.

27. The composition of claim 1 which is a dietary supplement.

28. The composition of claim 6, wherein the quantity by weight of the unsaponifiable fraction in the lupine oil concentrate is about 45% to about 65%.

29. The composition of claim 11, wherein said use is selected from the group consisting of a cosmetic composition an antioxidant, an anti-free radical agent, an antielastase agent, an agent for protecting against UVA and/or UVB, and an agent for protecting DNA against damage.

9. A composition comprising polyphenol derivatives extracted from lupine oil for use as an antioxidant and/or antielastase.

10. The composition of claim 9, comprising at least 20 ppm of said phenol derivatives.