Process for the preparation of a granulate suitable to the preparation of rapidly disintegrable mouth-soluble tablets and compositions obtained thereby

  • US 6,149,938 A
  • Filed: 07/23/1998
  • Issued: 11/21/2000
  • Est. Priority Date: 07/25/1997
  • Status: Expired due to Term
First Claim
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1. A process for making a granulate for use in the preparation of mouth-soluble, rapidly disintegrating tablets, which process comprises:

  • (i) granulating in a fluidized bed(a) a polyalcohol;

    (b) an active ingredient;

    (c) from 1 to 30% of an edible acid wherein the edible acid is not part of an effervescent mixture consisting of an acid and a base;

    (d) optionally, other solid components selected from the group consisting of lubricants, sweetening agents, and flavors; and

    (e) an aqueous solution or aqueous dispersion of a water-soluble or water-dispersible polymer that provides 1-10% of the final weight of the granulate; and

    (ii) drying the granulate in the fluidized bed.

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