Gaseous ultrasound contrast media and method for selecting gases for use as ultrasound contrast media
First Claim
1. An ultrasound contrast medium comprising an aqueous carrier and free gas microbubbles, the free gas microbubbles including a combination of biocompatible gases, the combination including at least one fluorinated gas selected from the group consisting of octafluoropropane, dodecafluoropentane, and decafluorobutane.
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Accused Products
Abstract
Disclosed herein are agents for enhancing the contrast in an ultrasound image. These agents are extremely small bubbles, or "microbubbles," comprised of specially selected gases. The microbubbles described herein exhibit long life spans in solution and may be produced at a size small enough to traverse the lungs, thus enabling improved ultrasound imaging of the cardiovascular system and other vital organs. Also disclosed herein is a method for selecting gases from which contrast agents may be produced. The method is based on calculations using inherent physical properties of gases and describes a means to associate the properties of a gas with the time for dissolution of microbubbles comprised of the gas.
33 Citations
12 Claims
- 1. An ultrasound contrast medium comprising an aqueous carrier and free gas microbubbles, the free gas microbubbles including a combination of biocompatible gases, the combination including at least one fluorinated gas selected from the group consisting of octafluoropropane, dodecafluoropentane, and decafluorobutane.
- 7. An ultrasound contrast medium comprising a gas emulsion, the gas emulsion comprising an aqueous carrier and free gas microbubbles, the free gas microbubbles including a combination of biocompatible gases, the combination including at least one fluorinated gas selected from the group consisting of octafluoropropane, dodecafluoropentane, and decafluorobutane.
Specification