Process for making paroxetine

  • US 6,172,233 B1
  • Filed: 01/15/1998
  • Issued: 01/09/2001
  • Est. Priority Date: 01/15/1997
  • Status: Expired due to Fees
First Claim
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1. A process for industrial scale preparation of a compound of structure (2) in which R and R′

  • are independently selected from an alkyl, aryl, or arylalkyl group, X is fluorine which comprises reacting a compound of structure (4) with an organometallic compound having one or more X-substituted phenyl groups, in a suitable organic solvent, provided that the solvent is not wholly an ether solvent when the organometallic compound is a Grignard reagent.

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