Oral suspension of pharmaceutical substance

  • US 6,184,220 B1
  • Filed: 03/25/1999
  • Issued: 02/06/2001
  • Est. Priority Date: 03/27/1998
  • Status: Expired due to Term
First Claim
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1. A pharmaceutical composition of matter which is an orally administered suspension comprisingparticles of a non-steroidal anti-inflammtory active substance selected from the acid enolcarboxamides (oxicams), and pharmaceutically acceptable salts thereof, having a suspendable particle size spectrum in which at least 90% of the particles are smaller than 50 μ

  • m, a physiologically inert dispersion medium in which the particles of active substance are suspended and in which dispersion medium the active substance has a solubility of less than 500 μ

    g/ml, about 0.1 to about 5% by weight of highly dispersed silicon dioxide having a specific surface area of at least 50 m2/g, forming a three-dimensional siloid structure produced by adding the silicon dioxide to the dispersion medium with the action of shear forces characterised by a circumferential rotor speed of about 15 to 35 m/s, and about 0.05 to about 2% by weight of a hydrophilic polymer, which polymer is soluble in the dispersion medium.

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