Analgesic immediate and controlled release pharmaceutical composition

  • US 6,194,000 B1
  • Filed: 04/17/1998
  • Issued: 02/27/2001
  • Est. Priority Date: 10/19/1995
  • Status: Expired due to Term
First Claim
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1. A method of preparing an analgesic pharmaceutical composition for the administration of an NMDA receptor antagonist to a human or animal subject for the treatment of pain, comprising:

  • providing a matrix or coated core containing an NMDA receptor antagonist to provide sustained release of a NMDA receptor antagonist;

    providing a mixture containing a NMDA receptor antagonist to provide an immediate release of a NMDA receptor antagonist; and

    combining the matrix or coated core with the mixture, the immediate release form and sustained release form being present in sufficient amounts to diminish or abolish wind-up.

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