Prostate implant planning engine for radiotherapy

• US 6,200,255 B1
• Filed: 10/30/1998
• Issued: 03/13/2001
• Est. Priority Date: 10/30/1998
• Status: Expired due to Fees

• Current Assignee: University of Rochester
• Original Assignee: University of Rochester
• Inventors: Yu, Yan
• Primary Examiner(s): Gilbert, Samuel G.
• Assistant Examiner(s): Cadugan, Joseph A.
• Application Number:
  US09/182,228
• Time in Patent Office: 865 Days
• Field of Search: 600/1-8, 600/427, 600/439, 434/262-275, 378/65
• US Class Current: 600/1
• CPC Class Codes: A61N 5/1001 using radiation sources introduced into or applied onto the body; brachytherapy
• CPC Class Codes: A61N 5/1031 using a specific method of dose optimization

Abstract

An implant planning engine plans implants for radiotherapy, e.g., prostrate brachytherapy. The system optimizes intraoperative treatment planning on a real-time basis using a synergistic formulation of a genetic algorithm, multi-objective decision theory and a statistical sensitive analysis. A total solution for prostate seed implant brachytherapy is achieved.

Claims

1. A method for intraoperative treatment planning for prostate seed implant therapy, comprising the steps of:

setting up a patient who is to receive prostate seed implant therapy in an operating room;

determining at least one of the position and volume of the patient'"'"'s prostate; and

determining the optimal placement of said prostate seeds to be implanted;

wherein each of said steps recited above is performed in sequence one after the other in real time while the patient is in the operating room;

and further including the step of determining the degree of pubic arch interference inherent in the determination of the placement of said prostate seeds to be implanted.

2. The method of claim 1, further including the step of modifying said determination of the placement of said prostate seeds to be implanted based upon a predetermined degree of pubic arch interference.

3. A method for the real time intraoperative treatment planning for prostate seed implant therapy in which said seeds are carried by needles comprising the steps of:

determining at least one of the position and volume of a patient'"'"'s prostate;

generating a surgical template representative of said prostate;

encoding a two-dimensional binary pattern representative of all potential needle placement positions within said surgical template; and

calculating the optimal solution of needle and seed locations for treatment of said prostate;

generating a three-dimensional virtual surgical scene for displaying visual confirmation of needle placement within said prostate;

inserting said needles in said prostate; and

comparing actual needle placement using an x-ray device to said visual confirmation of said needle placement shown by said virtual surgical scene.

4. A method for the real time intraoperative treatment planning for prostate seed implant therapy in which said seeds are carried by needles, comprising the steps of:

determining at least one of the position and volume of a patient'"'"'s prostate;

generating a surgical template representative of said prostate;

encoding a two-dimensional binary pattern representative of all potential needle placement positions within said surgical template;

calculating the optimal solution of needle and seed locations for treatment of said prostate; and

determining the degree of pubic arch interference present in said optimal solution of needle and seed locations.

6. The method of claim 4, further including the step of modifying said optimal solution of needle and seed locations based upon a predetermined degree of pubic arch interference.

5. A method for the real time intraoperative treatment planning for prostate seed implant therapy in which said seeds are carried be needles, comprising the steps of:

determining at least one of the position and volume of a patient'"'"'s prostate;

generating a surgical template representative of said prostate;

encoding a two-dimensional binary pattern representative of all potential needle placement positions within said surgical template;

calculating the optimal solution of needle and seed locations for treatment of said prostate; and

generating a three-dimensional virtual surgical scene for displaying visual confirmation of needle placement within said prostate;

wherein said surgical scene is shown in a natural horizon that mirrors an operating room view.

7. A system for the real time intraoperative treatment planning for prostate seed implantation therapy, comprising:

an operating room for setting up a patient whose prostate is to be treated with said prostate seed implantation therapy;

means for determining at least one of the position and volume of said prostate and for generating a surgical implantation template representative of said prostate;

means for determining the optimal placement of prostate seeds to be implanted;

a three-dimensional virtual surgical scene for displaying said prostate, said surgical implantation template and optimal placement of said prostate seeds to be implanted; and

means for determining the degree of pubic arch interference present in said optimal solution of said prostate seeds to be implanted.

8. A system for the real time intraoperative treatment planning for prostate seed implantation therapy, comprising:

an operating room for setting up a patient whose prostate is to be treated with said prostate seed implantation therapy;

means for determining at least one of the position and volume of said prostate and for generating a surgical implantation template representative of said prostate;

means for determining the optimal placement of prostate seeds to be implanted;

a three-dimensional virtual surgical scene for displaying said prostate, said surgical implantation template and optimal placement of said prostate seeds to be implanted; and

means for modifying said optimal solution of said prostate seeds to be implanted based upon a predetermined degree of pubic arch interference;

wherein said virtual surgical scene is continuously navigated and compared with a real-time ultrasound image of the surgical scene for verification of said prostate seed implantation in said prostate relative to the determined optimal placement of said prostate seeds.

9. A method for the real time intraoperative treatment planning for seed implant therapy in which said seeds are carried by needles, comprising the steps of:

determining at least one of the position and volume of a patient'"'"'s organ to be treated;

generating a surgical template representative of said organ;

encoding a two-dimensional binary pattern representative of all potential needle placement positions within said surgical template;

calculating the optimal solution of needle and seed locations for treatment of said organ;

generating a three-dimensional virtual surgical scene for displaying visual confirmation of needle placement within said organ;

inserting said needles in said organ; and

comparing actual needle placement using an x-ray device to said visual confirmation of said needle placement shown by said virtual surgical scene.