Calcium receptor-active compounds

CAFC
  • US 6,211,244 B1
  • Filed: 10/23/1995
  • Issued: 04/03/2001
  • Est. Priority Date: 10/21/1994
  • Status: Expired due to Term
First Claim
Patent Images

1. A compound having the formula:

  • wherein Ar5 is either naphthyl or phenyl optionally substituted with 0 to 5 substituents each independently selected from the group consisting of, lower alkyl, halogen, lower alkoxy, lower thioalkyl, methylene dioxy, lower haloalkyl, lower haloalkoxy, OH, CH2OH, CONH2, CN, acetoxy, benzyl, benzyloxy, α



    -dimethylbenzyl, NO2, CHO, CH3CH(OH), acetyl, ethylene dioxy, and —

    CH═

    CH-phenyl;

    Ar6 is phenyl substituted with 1 to 5 substituents each independently selected from the group consisting of acetyl, lower alkyl, halogen, lower alkoxy, lower thioalkyl, methylene dioxy, lower haloalkyl, lower haloalkoxy, OH, CH2OH, CONH2, CN, carbomethoxy, OCH2C(O)C2H5 and OCH2C(O)OC2H5 and acetoxy, provided that at least one substituent is OCH2C(O)OC2H5;

    R11 is hydrogen or methyl; and

    R12 is hydrogen or methyl;

    provided that at least one of R11 and R12 is methyl;

    or a pharmaceutically acceptable salt or complex thereof.

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